Anti-atrophin-1 interacting protein 4 (AIF4, ITCH, itchy homolog E3 ubiquitin protein ligase (mouse)

Anti-atrophin-1 interacting protein 4 (AIF4, ITCH, itchy homolog E3 ubiquitin protein ligase (mouse)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A4156-17.100 100 µg - -

3 - 19 business days*

725.00€
 
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral... more
Product information "Anti-atrophin-1 interacting protein 4 (AIF4, ITCH, itchy homolog E3 ubiquitin protein ligase (mouse)"
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral andpallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:32000, Western Blot: 0.03-0.1ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: EC=6.3.2.-, Anti-NFE2-associated polypeptide 1, Anti-Atrophin-1-interacting protein 4, Anti-E3 ubiquitin-protein ligase Itchy homolog
Supplier: United States Biological
Supplier-Nr: A4156-17

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Goat
Reactivity: Dog, Human, Mouse, Rat
Immunogen: Synthetic peptide of AIF4.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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