Anti-ASAP2 (Arf-GAP with SH3 Domain, ANK Repeat and PH Domain-containing Protein 2, Development and

Anti-ASAP2 (Arf-GAP with SH3 Domain, ANK Repeat and PH Domain-containing Protein 2, Development and
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A3334-96.100 100 µg - -

3 - 19 business days*

629.00€
 
ASAP2 is a multidomain protein belonging to the beta family with two ANK repeats, an Arf-GAP... more
Product information "Anti-ASAP2 (Arf-GAP with SH3 Domain, ANK Repeat and PH Domain-containing Protein 2, Development and"
ASAP2 is a multidomain protein belonging to the beta family with two ANK repeats, an Arf-GAP domain, a PH domain and a SH3 domain. This protein localizes in the Golgi apparatus and also at the plasma membrane where it colocalizes with protein tyrosine kinase 2-beta (PYK2) and forms a stable complex with PYK2 in vivo. ASAP2 is tyrosine phosphorylated by activated PYK2. It functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. ASAP2 activates the small GTPases ARF1, ARF5 and ARF6 and regulates the formation of post-Golgi vesicles and modulates constitutive secretion. It modulates phagocytosis mediated by Fc gamma receptor and ARF6. Usually detected in heart, brain, placenta, kidney, monocytes and pancreas, it is up-regulated during monocyte maturation. Multiple transcript variants encoding different isoforms have been found. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml, Optimal dilutions to be determined by the researcher. Positive Control: Human Brain lysate, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-Pyk2 C-terminus-associated protein, Anti-Development and differentiation-enhancing factor 2, Anti-Paxillin-associated protein with ARF GAP activity 3, Anti-Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2
Supplier: United States Biological
Supplier-Nr: A3334-96

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: Synthetic peptide corresponding to aa700-750 of human ASAP2.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-ASAP2 (Arf-GAP with SH3 Domain, ANK Repeat and PH Domain-containing Protein 2, Development and"
Write a review
or to review a product.
Viewed