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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-36-2636-20 | 20 µg | - |
3 - 11 business days* |
375.00€
|
|||
ABE-36-2636-100 | 100 µg | - |
3 - 11 business days* |
853.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The ADP-ribosylation factor (ARF) family comprises a group of structurally and functionally... more
Product information "Anti-ARF1 (Golgi Apparatus Marker) Monoclonal Antibody (Clone: 3F1)"
The ADP-ribosylation factor (ARF) family comprises a group of structurally and functionally conserved proteins, which are members of the Ras superfamily of regulatory GTP-binding proteins. The ARF family is divided functionally into the ARF and the ARF-like proteins. ARF's share more than 60% sequence identity, appear to be ubiquitous in eukaryotes, and are highly conserved evolutionarily. ARF is involved in intracellular protein traffic to and within the Golgi complex. ARF has a number of disparate activities including maintenance of organelle integrity, assembly of coat proteins, as a co-factor for cholera toxin and as an activator of phospholipase D. Protein function: GTP-binding protein involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity, the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD). [The UniProt Consortium]
Keywords: | Anti-ARF1, Anti-ADP-ribosylation factor 1, Anti-ARF1 (Golgi Apparatus Marker) Monoclonal Antibody (Clone: 3F1) |
Supplier: | Abeomics |
Supplier-Nr: | 36-2636 |
Properties
Application: | ELISA, IF, WB, IHC |
Antibody Type: | Monoclonal |
Clone: | 3F1 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human, mouse, rat |
Immunogen: | Synthetic peptide SNQLRNQ, corresponding to C terminal amino acids 174-180 of Human ARF1. |
Database Information
KEGG ID : | K07937 | Matching products |
UniProt ID : | P84077 | Matching products |
Gene ID | GeneID 375 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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