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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V3202SAF-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
1 mg/ml in 1X PBS, BSA free, sodium azide free. Recognizes a protein of 102kDa, identified as... more
Product information "Anti-Alpha Catenin, clone 1G5"
1 mg/ml in 1X PBS, BSA free, sodium azide free. Recognizes a protein of 102kDa, identified as Catenin, alpha-1. Catenins comprise a large family of Ca2+-dependent, homotypic cell-cell adhesion molecules that play important roles in development, epithelial cell polarity and tumor progression. Alpha-Catenin is a key regulator of actin dynamics in cell-cell adhesion. During cell-cell adhesion, alpha-Catenin forms a heterodimer with beta-Catenin and links the cadherins to actin associated with the cytoskeleton. Alpha-Catenin also regulates the beta-Catenin signaling in various cells. It displays the tumor suppressor activity and is found to be down regulated in some forms of breast cancer. Protein function: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation. [The UniProt Consortium]
Keywords: | Anti-CTNNA1, Anti-Catenin alpha-1, Anti-Alpha E-catenin, Anti-Cadherin-associated protein, Anti-Renal carcinoma antigen NY-REN-13, Alpha Catenin Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V3202SAF |
Properties
Application: | FC, IF, WB |
Antibody Type: | Monoclonal |
Clone: | 1G5 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A human fusion protein was used as the immunogen for the Alpha Catenin antibody. |
Format: | Purified |
Database Information
KEGG ID : | K05691 | Matching products |
UniProt ID : | P35221 | Matching products |
Gene ID | GeneID 1495 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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