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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-35-1554-50 | 50 µl | - |
3 - 11 business days* |
574.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly... more
Product information "Anti-4E-BP1 (Ab-45)"
4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. Protein function: Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. [The UniProt Consortium]
Keywords: | Anti-4E-BP1, Anti-PHAS-I, Anti-EIF4EBP1, Anti-eIF4E-binding protein 1, Anti-Eukaryotic translation initiation factor 4E-binding protein 1, Anti-Phosphorylated heat- and acid-stable protein regulated by insulin 1, Polyclonal Antibody to 4E-BP1 (Ab-45) |
Supplier: | Abeomics |
Supplier-Nr: | 35-1554-50 |
Properties
Application: | WB, IHC, IF |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Peptide sequence around aa.43~47 (S-T-T-P-G) derived from Human 4E-BP1. |
Format: | Purified |
Database Information
KEGG ID : | K07205 | Matching products |
UniProt ID : | Q13541 | Matching products |
Gene ID | GeneID 1978 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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