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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
P4072-03W.5 | 5 µg | - | - |
3 - 19 business days* |
1,166.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Cyclic AMP-dependent phosphodiesterase type D (PDE4D) family is comprise of 5 variants (PDE4D1,... more
Product information "Phosphodiesterase 4D3, Recombinant, Human (PDE4D3)"
Cyclic AMP-dependent phosphodiesterase type D (PDE4D) family is comprise of 5 variants (PDE4D1, D2, D3, D4 and D5, 1, 2). One or more PDE4D subtype-variants are ubiquitously present in all mammalian cells. In CNS all five PDE4D subtype-variants are expressed in varying ratios and their activity is regulated in tandem with GPCRs stimulation. Peripheral tissues also exhibit differential expression of PDE4D variants. PDE4D1/D2 mRNA levels rise in response to an increase in cAMP. Short-term regulation of PDE4D variants involved PKA, MAP kinases and Erk2 phosphorylation that results in rapid change in their enzymatic activities. Other regulatory mechanism involved protein-protein interactions with cytoskeletal scaffolding proteins. Description: Recombinant human PDE4D3 (GenBank Accession No. NM_006203, full length, with N-terminal GST tag, expressed in an Baculovirus infected Sf9 cell expression system. Specific Activity: ~5000pmol/min/ug, Assay Conditions: 10mM Tris-HCl, pH 7.4, 10mM MgCl2, 1mM MnCl2, 200uM cAMP, 0.1mg/ml BSA, 0.2ng/ul P4072-03W at 37ºC for 20 minutes. Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | DPDE3, PDE43, EC=3.1.4.17, cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
Supplier: | United States Biological |
Supplier-Nr: | P4072-03W |
Properties
Conjugate: | No |
MW: | 102.4 kD |
Purity: | 70% |
Format: | Purified |
Database Information
KEGG ID : | K13293 | Matching products |
UniProt ID : | Q08499 | Matching products |
Gene ID | GeneID 5144 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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