204 products were found matching "K13293"!

Nerandomilast is an inhibitor of phosphodiesterase 4B (PDE4B. IC50 = 0. µM). It is selective for PDE4B over PDE4A, PDE4C, and PDE4D (IC50s = 0. 8. and 0. µM, respectively), PDE7A, PDE3A, PDE1C, and PDE9A (IC50s = 14, 120, 46, and >100 µM, respectively), and does not inhibit PDE2A, PDE5, or PDE6. Nerandomilast...

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. PDE4B antibody detects Phosphodiesterase 4B, an enzyme that hydrolyzes cyclic AMP (cAMP) into AMP, terminating cAMP-dependent signaling. PDE4B belongs to the type 4 phosphodiesterase family, which provides fine control of intracellular cAMP...

Type 4 cyclic nucleotide phosphodiesterases (PDE4) isoforms selectively inactivate the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP. (±)-Rolipram is a cell-permeable selective PDE4 inhibitor. Since PDE4 is abundant in leukocytes, (±)-rolipram inhibits inflammation by suppressing...

Bucladesine is a cell-permeable, cyclic nucleotide derivative that mimics the action of endogenous cyclic adenosine monophosphate (cAMP) and is a phosphodiesterase inhibitor. Because it mimics cAMP and can induce normal physiological responses when added to cells in experimental conditions, bucladesine is widely...

Ro 20-1724 is a cell-permeable, cAMP-specific phosphodiesterase type IV (PDE4) inhibitor (IC50 = 2 µM). It weakly inhibits PDE3 with a Ki value greater than 25 µM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. It is often...

Apremilast is an inhibitor of phosphodiesterase 4 (PDE4) with an IC50 value of 74 nM when tested in U937 cell lysates with 1 mM cAMP. It is orally active, significantly decreasing epidermal thickness and epithelial cell proliferation index in a mouse model of psoriasis. Apremilast reduces both TNF-alpha and matrix...

The PDE4A Assay Kit is designed for identification of PDE4A inhibitors using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE4A to the binding agent. PDE4A is widely expressed in brain tumors and promotes their growth and its inhibitor Rolipram...

Active human PDE4D3 (GenBank Accession No. U50159), full length, with N-terminal GST tag, MW=102.4 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Active human PDE4A1A (GenBank Accession No. U97584), full length with N-terminal GST tag, MW= 100 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Active human PDE4B1 (GenBank Accession No. NM_001037341), full length with N-terminal GST tag, MW= 109 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Drotaverine is an alkaloid that has been described as an inhibitor of phosphodiesterase 4 and negative allosteric modulator of L-type Ca2+ channels.Formal Name: 1-[(3,4-diethoxyphenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydro-isoquinoline, monohydrochloride. CAS Number: 985-12-6. Molecular Formula: C24H31NO4 . HCl....

Apremilast, also known as CC-10004, is a novel and potent small-molecule inhibitor of phosphodiesterase 4 (PDE4), a key enzyme involved in cyclic adenosine monophosphate (cAMP) degradation and cytokine production of inflammatory cells.