LRRKtide (trifluoroacetate salt)

LRRKtide is a peptide substrate for leucine-rich repeat kinase 2 (LRRK2), an enzyme frequently mutated in patients with Parkinson's disease, that corresponds to amino acids 550-564 of membrane-organizing extension spike protein (moesin). It has been used to identify inhibitors of LRRK2.Formal Name: L-arginyl-L-leucylglycyl-L-arginyl-L-alpha-aspartyl-L-lysyl-L-tyrosyl-L-lysyl-L-threonyl-L-leucyl-L-arginyl-L-glutaminyl-L-isoleucyl-L-arginyl-L-glutamine, trifluoroacetate salt. Synonyms: Membrane-organizing Extension Spike Protein (550-564), Moesin (550-564). Molecular Formula: C83H147N31O22 . XCF3COOH. Formula Weight: 1931.3. Purity: >98%. Formulation: (Request formulation change), A solid. Peptide Sequence: RLGRDKYKTLRQIRQ-OH. Solubility: Water: Soluble. SMILES: OC(C(F)(F)F)=O.O=C(N[C@H](C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN[H])C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@@H](CCCCN[H])C(N[C@]([C@H](O)C)([H])C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)[C@H](CCCNC(N)=N)N[H]. InChi Code: InChI=1S/C83H147N31O22.C2HF3O2/c1-8-44(6)64(77(133)107-53(22-16-36-100-83(95)96)70(126)108-55(79(135)136)28-30-61(88)118)113-73(129)54(27-29-60(87)117)106-69(125)52(21-15-35-99-82(93)94)105-74(130)57(38-43(4)5)112-78(134)65(45(7)115)114-72(128)51(19-10-12-32-85)104-75(131)58(39-46-23-25-47(116)26-24-46)110-71(127)50(18-9-11-31-84)103-76(132)59(40-63(120)121)111-68(124)49(20-14-34-98-81(91)92)102-62(119)41-101-67(123)56(37-42(2)3)109-66(122)48(86)17-13-33-97-80(89)90,3-2(4,5)1(6)7/h23-26,42-45,48-59,64-65,115-116H,8-22,27-41,84-86H2,1-7H3,(H2,87,117)(H2,88,118)(H,101,123)(H,102,119)(H,103,132)(H,104,131)(H,105,130)(H,106,125)(H,107,133)(H,108,126)(H,109,122)(H,110,127)(H,111,124)(H,112,134)(H,113,129)(H,114,128)(H,120,121)(H,135,136)(H4,89,90,97)(H4,91,92,98)(H4,93,94,99)(H4,95,96,100),(H,6,7)/t44-,45+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,64-,65-,/m0./s1. InChi Key: YFJHASJMGFNSEN-GFRJOXKZSA-N.