LL-37 (13-37) (human) (trifluoroacetate salt)

LL-37 (13-37) is an anticancer peptide fragment of LL-37 (Cay-24461). It inhibits the ATPase activity of ATP-binding cassette transporter 2, subfamily G (ABCG2) when used at a concentration of 1 µM. LL-37 (13-37) induces cytotoxicity in wild-type SW620 cells and SW620 cells overexpressing P-glycoprotein (P-gp), also known as multidrug resistance protein 1 (MDR1, IC50s = 25.5 and 27.3 µM, respectively), as well as wild-type MCF-7 cells, MCF-7 cells overexpressing ABCG2, and MCF-7 cells overexpressing multidrug resistance-associated protein 1 (MRP1, IC50s = 33.1, 31.8, and 31.1 µM, respectively). It potentiates cytotoxicity induced by mitoxantrone (Cay-14842) in MCF-7 and HEK293 cells overexpressing ABCG2 when used at concentrations of 5 or 10 µM but not cytotoxicity induced by cisplatin (Cay-13119) in HEK293 cells overexpressing ABCG2, paclitaxel (Cay-10461) in SW620 cells overexpressing P-gp, or doxorubicin (Cay-15007) in MCF-7 cells overexpressing MRP1 at the same concentrations. LL-37 (13-37) (10, 20, or 40 µM) decreases mitoxantrone drug efflux by, and increases mitoxantrone levels in, MCF-7 cells overexpressing ABCG2.Formal Name: L-isoleucylglycyl-L-lysyl-L-alpha-glutamyl-L-phenylalanyl-L-lysyl-L-arginyl-L-isoleucyl-L-valyl-L-glutaminyl-L-arginyl-L-isoleucyl-L-lysyl-L-alpha-aspartyl-L-phenylalanyl-L-leucyl-L-arginyl-L-asparaginyl-L-leucyl-L-valyl-L-prolyl-L-arginyl-L-threonyl-L-alpha-glutamyl-L-serine, trifluoroacetate salt. Synonyms: CAP-18, hCAP-18, Cathelicidin, FALL-39, IG-25, LL-13, LL-25. Molecular Formula: C137H232N42O36 . XCF3COOH. Formula Weight: 3043.6. Purity: >95%. Formulation: (Request formulation change), A solid. Peptide Sequence: IGKEFKRIVQRIKDFLRNLVPRTES-OH. Solubility: DMSO: Soluble: >10 mg/ml, PBS (pH 7.2): Soluble: >10 mg/ml. SMILES: OC(C(F)(F)F)=O.CC[C@H](C)[C@](C(NCC(N[C@@H](CCCCN[H])C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@@H](CCCNC(N)=N)C(N[C@@](C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@](C(N[C@@H](CCCCN[H])C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@@H](C(C)C)C(N1CCC[C@H]1C(N[C@@H](CCCNC(N)=N)C(N[C@]([C@H](O)C)([H])C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)CC(C)C)=O)CC2=CC=CC=C2)=O)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)([H])N[H]. InChi Code: InChI=1S/C137H232N42O36.C2HF3O2/c1-16-74(12)104(143)127(208)156-68-100(184)157-80(40-25-28-54-138)110(191)162-88(49-52-101(185)186)115(196)169-92(64-78-36-21-19-22-37-78)121(202)160-81(41-26-29-55-139)111(192)158-84(44-32-58-153-135(146)147)118(199)177-108(76(14)18-3)130(211)174-105(72(8)9)128(209)165-87(48-51-98(141)182)114(195)159-85(45-33-59-154-136(148)149)117(198)176-107(75(13)17-2)129(210)164-82(42-27-30-56-140)112(193)172-95(67-103(189)190)124(205)170-93(65-79-38-23-20-24-39-79)122(203)167-90(62-70(4)5)120(201)161-83(43-31-57-152-134(144)145)113(194)171-94(66-99(142)183)123(204)168-91(63-71(6)7)125(206)175-106(73(10)11)132(213)179-61-35-47-97(179)126(207)163-86(46-34-60-155-137(150)151)119(200)178-109(77(15)181)131(212)166-89(50-53-102(187)188)116(197)173-96(69-180)133(214)215,3-2(4,5)1(6)7/h19-24,36-39,70-77,80-97,104-109,180-181H,16-18,25-35,40-69,138-140,143H2,1-15H3,(H2,141,182)(H2,142,183)(H,156,208)(H,157,184)(H,158,192)(H,159,195)(H,160,202)(H,161,201)(H,162,191)(H,163,207)(H,164,210)(H,165,209)(H,166,212)(H,167,203)(H,168,204)(H,169,196)(H,170,205)(H,171,194)(H,172,193)(H,173,197)(H,174,211)(H,175,206)(H,176,198)(H,177,199)(H,178,200)(H,185,186)(H,187,188)(H,189,190)(H,214,215)(H4,144,145,152)(H4,146,147,153)(H4,148,149,154)(H4,150,151,155),(H,6,7)/t74-,75-,76-,77+,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,104-,105-,106-,107-,108-,109-,/m0./s1. InChi Key: BRVMMWFETMTKKJ-GIYKNBIXSA-N.