CXCL9 (74-103) (human) (trifluoroacetate salt)

Chemokine (C-X-C motif) ligand 9 (CXCL9) (74-103) is a C-terminal fragment of mature CXCL9. It binds to the glycosaminoglycan heparin in a cell-free assay (Kd = 3.1 nM). CXCL9 (74-103) inhibits the binding of CXCL8 or CXCL11 to heparin, as well as chemokine (C-C motif) ligand 2 (CCL2) binding to heparan sulfate, in a concentration-dependent manner. Unlike full-length CXCL9, CXCL9 (74-103) does not increase intracellular calcium levels in CHO cells expressing human CXC receptor 3 (CXCR3). CXCL9 (74-103) reduces the cytopathogenic effect of respiratory syncytial virus (RSV) in HeLa cells, herpes simplex virus 1 (HSV-1) in human embryonic lung (HEL) cells, and dengue virus serotype 2 in HMEC-1 cells (EC50s = 23, 15, and 11 µM, respectively). It inhibits CXCL8 (1-77)- or monosodium urate-induced neutrophil extravasation to the tibiofemoral articulation in mouse models of acute inflammation or gout, respectively, when administered at a dose of 100 µg/animal. CXCL9 (74-103) increases survival and decreases liver neutrophil infiltration and necrosis in a mouse model of liver injury induced by acetaminophen (Cay-10024). Intravenous administration of CXCL9 (74-103) (100 µl of a 1 mg/ml solution) decreases bronchoalveolar lavage fluid (BALF) neutrophil infiltration and IL-1beta levels, but does not reduce lung bacterial burden, in a mouse model of K. pneumoniae-induced pneumonia.Synonyms: Chemokine (C-X-C motif) Ligand 9 (74-103), MIG30, Monokine Induced by Interferon-gamma (74-103). Molecular Formula: C158H295N59O40 . XCF3COOH. Formula Weight: 3661.4. Purity: >98%. Formulation: (Request formulation change), A solid. Peptide Sequence: KKKQKNGKKHQKKKVLKVRKSQRSRQKKTT-OH. Solubility: Water: Soluble. SMILES: [H]N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@]([C@@H](C)O)([H])C(N[C@]([C@@H](C)O)([H])C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC1=CN=CN1)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C158H295N59O40.C2HF3O2/c1-86(2)78-112(148(249)202-103(49-20-33-73-170)146(247)214-123(87(3)4)152(253)208-107(53-37-77-187-158(182)183)136(237)195-101(47-18-31-71-168)139(240)212-116(84-219)151(252)207-111(57-61-120(176)225)144(245)201-106(52-36-76-186-157(180)181)140(241)213-115(83-218)150(251)203-105(51-35-75-185-156(178)179)135(236)205-109(55-59-118(174)223)141(242)196-97(43-14-27-67-164)133(234)200-104(50-21-34-74-171)147(248)216-125(89(7)220)154(255)217-126(90(8)221)155(256)257)211-153(254)124(88(5)6)215-145(246)102(48-19-32-72-169)199-132(233)95(41-12-25-65-162)194-131(232)96(42-13-26-66-163)197-143(244)110(56-60-119(175)224)206-149(250)113(79-91-81-184-85-189-91)209-137(238)99(45-16-29-69-166)192-129(230)93(39-10-23-63-160)190-122(227)82-188-128(229)114(80-121(177)226)210-138(239)100(46-17-30-70-167)198-142(243)108(54-58-117(173)222)204-134(235)98(44-15-28-68-165)193-130(231)94(40-11-24-64-161)191-127(228)92(172)38-9-22-62-159,3-2(4,5)1(6)7/h81,85-90,92-116,123-126,218-221H,9-80,82-84,159-172H2,1-8H3,(H2,173,222)(H2,174,223)(H2,175,224)(H2,176,225)(H2,177,226)(H,184,189)(H,188,229)(H,190,227)(H,191,228)(H,192,230)(H,193,231)(H,194,232)(H,195,237)(H,196,242)(H,197,244)(H,198,243)(H,199,233)(H,200,234)(H,201,245)(H,202,249)(H,203,251)(H,204,235)(H,205,236)(H,206,250)(H,207,252)(H,208,253)(H,209,238)(H,210,239)(H,211,254)(H,212,240)(H,213,241)(H,214,247)(H,215,246)(H,216,248)(H,217,255)(H,256,257)(H4,178,179,185)(H4,180,181,186)(H4,182,183,187),(H,6,7)/t89-,90-,92+,93+,94+,95+,96+,97+,98+,99+,100+,101+,102+,103+,104+,105+,106+,107+,108+,109+,110+,111+,112+,113+,114+,115+,116+,123+,124+,125+,126+,/m1./s1. InChi Key: FUXNRWJKZSPRHI-KZXWNIDCSA-N.