Substrates and Inhibitors

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Malantide (trifluoroacetate salt)
Malantide (trifluoroacetate salt)

Item number: Cay40150-1

Malantide is a synthetic peptide derived from the beta-subunit of human phosphorylase kinase and is a fluorescent substrate for PKA and PKC. Upon phosphorylation by PKA or PKC, the intrinsic tyrosine fluorescence decreases and can be used to quantify PKA and PKC activity. Malantide displays an emission at 302 nm...
Keywords: L-arginyl-L-threonyl-L-lysyl-L-arginyl-L-serylglycyl-L-seryl-L-valyl-L-tyrosyl-L-alpha-glutamyl-L-prolyl-L-leucyl-L-lysyl-...
Application: Fluorescent PKA / PKC substrate
MW: 1633.9 D
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NucView(R) 488 Caspase-3 Substrate, 1mM in DMSO
NucView(R) 488 Caspase-3 Substrate, 1mM in DMSO

Item number: BOT-10402

NucView(R) 488 Caspase-3 Substrate is a novel cell membrane-permeable fluorogenic caspase substrate designed for detecting caspase-3/7 activity within live cells in real time. Unlike conventional caspase assays, NucView(R) 488 Caspase-3 Substrate detects caspase-3/7 activity within individual intact cells without...
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NucView(R) 488 Caspase-3 Substrate, 1mM in 1X PBS
NucView(R) 488 Caspase-3 Substrate, 1mM in 1X PBS

Item number: BOT-10403

NucView(R) 488 Caspase-3 Substrate is a novel fluorogenic caspase substrate for real-time detection of caspase-3/7 activity in live cells. In apoptotic cells, the substrate is cleaved to release a DNA dye that stains the nucleus with bright green fluorescence. 1 mM in PBS, 100 uL.
From 111.00€ *
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Ac-DEVD-CHO, Caspase-3 Inhibitor (5 mg)
Ac-DEVD-CHO, Caspase-3 Inhibitor (5 mg)

Item number: BOT-10404

Ac-DEVD-CHO is a synthetic tetrapeptide competitive inhibitor for Caspase-3/7, and contains the amino acid sequence of the PARP cleavage site. Ac-DEVD-CHO can be used to inhibit Caspase-3/7 activity in apoptotic cells, and to study events downstream of Caspase-3/7 activation.Soluble in DMSOStore at 4°CC20H30N4O11MW:...
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NucView(R) 405 Caspase-3 Substrate, 1 mM in DMSO
NucView(R) 405 Caspase-3 Substrate, 1 mM in DMSO

Item number: BOT-10405

NucView(R) 405 Caspase-3 Substrate, 1 mM in DMSO, provides a convenient tool for detecting apoptosis in intact cells based on caspase-3/7 activity using either confocal microscopy or flow cytometry. In contrast to other fluorogenic caspase substrates or fluorescent caspase inhibitor based (FLICA) assays, NucView(R)...
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NucView(R) 530 Caspase-3 Substrate, 1 mM in DMSO
NucView(R) 530 Caspase-3 Substrate, 1 mM in DMSO

Item number: BOT-10406

NucView 530 Caspase-3 Substrate, 1 mM in DMSO, provides a convenient tool for detecting caspase activity in intact cells in real time by either fluorescence microscopy or flow cytometry, the substrate stains apoptotic cell nuclei with orange fluorescence (Ex/Em 528/563 nm).
From 111.00€ *
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NucView(R) 405 Caspase-3 Substrate, 1 mM in 1X PBS
NucView(R) 405 Caspase-3 Substrate, 1 mM in 1X PBS

Item number: BOT-10407

NucView(R) 405 Caspase-3 Substrate, 1 mM in PBS, provides a convenient tool for detecting apoptosis in intact cells based on caspase-3/7 activity using either confocal microscopy or flow cytometry. In contrast to other fluorogenic caspase substrates or fluorescent caspase inhibitor based (FLICA) assays, NucView(R)...
From 111.00€ *
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NucView(R) 530 Caspase-3 Substrate, 1 mM in 1X PBS
NucView(R) 530 Caspase-3 Substrate, 1 mM in 1X PBS

Item number: BOT-10408

NucView(R) 530 Caspase-3 Substrate, 1 mM in PBS, provides a convenient tool for detecting apoptosis in intact cells based on caspase-3/7 activity using either confocal microscopy or flow cytometry. In contrast to other fluorogenic caspase substrates or fluorescent caspase inhibitor based (FLICA) assays, NucView(R)...
From 111.00€ *
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Ac-DEVD-aminoluciferin
Ac-DEVD-aminoluciferin

Item number: ABD-13210

Molecular weight: 779.79. Extinction coefficient (cm^-1 M^-1): 18000. Excitation (nm): 362. Emission (nm): 499. Ac-DEVD-aminoluciferin is a luminogenic substrate that measures caspase-3 and -7 activities in apoptotic cells. Caspases, a family of aspartate-specific cysteine proteases, are key regulators of apoptosis,...
Application: Luminogenic caspase-3/-7 substrate
MW: 779.79 D
120.00€ *
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Z-LETD-aminoluciferin
Z-LETD-aminoluciferin

Item number: ABD-13212

Molecular weight: 871.93. Extinction coefficient (cm^-1 M^-1): 18000. Excitation (nm): 362. Emission (nm): 499. Z-LETD-aminoluciferin is a luminogenic substrate that measures caspase-8 activity in apoptotic cells. Caspases, a family of aspartate-specific cysteine proteases, are key regulators of apoptosis,...
Application: Luminogenic caspase-8 substrate
MW: 871.93 D
868.00€ *
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Z-LEHD-aminoluciferin
Z-LEHD-aminoluciferin

Item number: ABD-13213

Molecular weight: 1021.99. Extinction coefficient (cm^-1 M^-1): 18000. Excitation (nm): 362. Emission (nm): 499. Z-LEHD-aminoluciferin is a luminogenic substrate that measures caspase-9 activity in apoptotic cells. Caspases, a family of aspartate-specific cysteine proteases, are key regulators of apoptosis,...
Application: Luminogenic caspase-9 substrate
MW: 1021.99 D
868.00€ *
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Z-IETD-aminoluciferin
Z-IETD-aminoluciferin

Item number: ABD-13214

Molecular weight: 871.93. Extinction coefficient (cm^-1 M^-1): 18000. Excitation (nm): 362. Emission (nm): 499. Z-IETD-aminoluciferin is a luminogenic substrate that measures caspase-6 and granzyme B activities in apoptotic cells. Caspases, a family of aspartate-specific cysteine proteases, are key regulators of...
Application: Luminogenic caspase-6/granzyme B substrate
MW: 871.93 D
1,117.00€ *
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2 from 35 pages