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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay24711-1 | 1 mg | - |
6 - 10 business days* |
294.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Urotensin II is a somatostatin-like neuropeptide agonist of the urotensin II receptor (UTR, Ki =... more
Product information "Urotensin II (human) (trifluoroacetate salt)"
Urotensin II is a somatostatin-like neuropeptide agonist of the urotensin II receptor (UTR, Ki = 2 nM). It increases intracellular calcium levels in a concentration-dependent manner in HEK293 cells expressing human UTR (EC50 = 0.6 nM). Urotensin II increases the level of reactive oxygen species (ROS) in pulmonary artery smooth muscle cells and induces proliferation, an effect that is inhibited by depletion of NADPH oxidase subunits. Urotensin II potently induces contraction of isolated rat thoracic aorta with an EC50 of 0.8 nM. It also induces contraction of isolated cynomolgus monkey arterial, but not venous, vessels and, when administered at doses greater than 100 pmol/kg, can lead to severe myocardial depression and fatal circulatory collapse.Formal Name: L-alpha-glutamyl-L-threonyl-L-prolyl-L-alpha-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-tyrosyl-L-cysteinyl-L-valine, cyclic (5->10)-disulfide, trifluoroacetate salt. Synonyms: hU II. Molecular Formula: C64H85N13O18S2 . XCF3COOH. Formula Weight: 1388.6. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Formic Acid: 1 mg/ml. SMILES: [H]N[C@@H](CCC(O)=O)C(N[C@]([C@@H](C)O)([H])C(N1CCC[C@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C2=O)CC3=CC=C(O)C=C3)=O)=O)CC4=CNC5=C4C=CC=C5)=O)CC6=CC=CC=C6)=O)CSSC[C@H](N2)C(N[C@@H](C(C)C)C(O)=O)=O)=O)CC(O)=O)=O)=O)=O.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C64H85N13O18S2.C2HF3O2/c1-33(2)52(64(94)95)75-61(91)48-32-97-96-31-47(73-59(89)46(29-51(82)83)72-62(92)49-17-11-25-77(49)63(93)53(34(3)78)76-54(84)40(66)22-23-50(80)81)60(90)70-43(26-35-12-5-4-6-13-35)56(86)71-45(28-37-30-67-41-15-8-7-14-39(37)41)58(88)68-42(16-9-10-24-65)55(85)69-44(57(87)74-48)27-36-18-20-38(79)21-19-36,3-2(4,5)1(6)7/h4-8,12-15,18-21,30,33-34,40,42-49,52-53,67,78-79H,9-11,16-17,22-29,31-32,65-66H2,1-3H3,(H,68,88)(H,69,85)(H,70,90)(H,71,86)(H,72,92)(H,73,89)(H,74,87)(H,75,91)(H,76,84)(H,80,81)(H,82,83)(H,94,95),(H,6,7)/t34-,40+,42+,43+,44+,45+,46+,47+,48+,49+,52+,53+,/m1./s1. InChi Key: MBEBYNOGELTOBF-SWXJRECRSA-N.
Keywords: | hU II, L-alpha-glutamyl-L-threonyl-L-prolyl-L-alpha-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-tyrosyl-L-cysteinyl-L-valine, cyclic (5->10)-disulfide, trifluoroacetate salt |
Supplier: | Cayman Chemical |
Supplier-Nr: | 24711 |
Properties
Application: | Urotensin-2 receptor agonist |
Conjugate: | No |
MW: | 1388.6 D |
Formula: | C64H85N13O18S2 . XCF3COOH |
Purity: | >95% |
Format: | Solid |
Database Information
KEGG ID : | K04241 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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