TT-232 (trifluoroacetate salt)

TT-232 is a synthetic peptide derivative of somatostatin. It binds to somatostatin receptors in isolated rat synaptosomal membranes (IC50 = ~0.1 nM). TT-232 (30 and 60 µg/ml) inhibits the proliferation of P388 murine and HL-60 human leukemia cells. In vivo, TT-232 (3-12 µg/animal per day) reduces tumor volume in an HL-60 mouse xenograft model. It inhibits intradermal neutrophil accumulation and ear edema induced by capsaicin (Cay-92350, Cay-10010743) in rats. TT-232 (5-20 µg/kg, i.p.) inhibits mechano-nociceptive hyperalgesia in rats.Formal Name: D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-cysteinyl-L-threoninamide cyclic (2->6)-disulfide, trifluoroacetate salt. Molecular Formula: C45H58N10O9S2 . XCF3COOH. Formula Weight: 947.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: Slightly soluble, DMSO: 12 mg/ml, Ethanol: Slightly soluble, PBS (pH 7.2): 0.3 mg/ml. SMILES: O=C([C@@H](NC([C@H](CSSC[C@H](NC([C@@H](NC1=O)CCCCN)=O)C(N[C@H](C(N)=O)[C@H](O)C)=O)NC([C@H](N)CC2=CC=CC=C2)=O)=O)CC3=CC=C(C=C3)O)N[C@@H]1CC4=CNC5=CC=CC=C54.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C45H58N10O9S2.C2HF3O2/c1-25(56)38(39(48)58)55-45(64)37-24-66-65-23-36(53-40(59)31(47)19-26-9-3-2-4-10-26)44(63)51-34(20-27-14-16-29(57)17-15-27)42(61)52-35(21-28-22-49-32-12-6-5-11-30(28)32)43(62)50-33(41(60)54-37)13-7-8-18-46,3-2(4,5)1(6)7/h2-6,9-12,14-17,22,25,31,33-38,49,56-57H,7-8,13,18-21,23-24,46-47H2,1H3,(H2,48,58)(H,50,62)(H,51,63)(H,52,61)(H,53,59)(H,54,60)(H,55,64),(H,6,7)/t25-,31-,33+,34+,35-,36+,37+,38+,/m1./s1. InChi Key: DONBUNHQHAMXKX-YWCUHKGISA-N.