SP-A (196-215) (human) (trifluoroacetate salt)

Surfactant protein A (SP-A) (196-215) is a synthetic peptide that corresponds to amino acids 196-215 of the C-terminal carbohydrate recognition domain of human SP-A. It inhibits LPS-induced TNF-alpha release in JAWSII mouse dendritic cells when used at concentrations of 1 and 10 µM. SP-A (196-215) (75 µM) induces phagocytosis of P. aeruginosa by JAWSII cells. Intratracheal administration of SP-A (196-215) (50 µg/animal) decreases disease severity and lung colony forming units in a mouse model of P. aeruginosa infection.Synonyms: SPA4, Surfactant Protein A. Molecular Formula: C107H145N29O35 . XCF3COOH. Formula Weight: 2397.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Peptide Sequence: GDFRYSDGTPVNYTNWYRGE-OH. Solubility: 10% ACN/H2O: Soluble. SMILES: [H]NCC(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(NCC(N[C@]([C@@H](C)O)([H])C(N1CCC[C@H]1C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCC(O)=O)C(O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)CC3=CNC4=C3C=CC=C4)=O)=O)=O)CC5=CC=C(O)C=C5)=O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)CC6=CC=C(O)C=C6)=O)=O)CC7=CC=CC=C7)=O)CC(O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C107H145N29O35.C2HF3O2/c1-51(2)86(134-101(166)77-19-12-36-136(77)104(169)88(53(4)139)133-82(147)49-119-90(155)74(44-84(150)151)129-100(165)76(50-137)132-94(159)69(39-56-22-28-60(141)29-23-56)124-91(156)65(18-11-35-116-107(113)114)123-93(158)67(37-54-13-6-5-7-14-54)126-98(163)75(45-85(152)153)121-80(145)46-108)102(167)130-72(42-78(109)143)96(161)127-70(40-57-24-30-61(142)31-25-57)99(164)135-87(52(3)138)103(168)131-73(43-79(110)144)97(162)128-71(41-58-47-117-63-16-9-8-15-62(58)63)95(160)125-68(38-55-20-26-59(140)27-21-55)92(157)122-64(17-10-34-115-106(111)112)89(154)118-48-81(146)120-66(105(170)171)32-33-83(148)149,3-2(4,5)1(6)7/h5-9,13-16,20-31,47,51-53,64-77,86-88,117,137-142H,10-12,17-19,32-46,48-50,108H2,1-4H3,(H2,109,143)(H2,110,144)(H,118,154)(H,119,155)(H,120,146)(H,121,145)(H,122,157)(H,123,158)(H,124,156)(H,125,160)(H,126,163)(H,127,161)(H,128,162)(H,129,165)(H,130,167)(H,131,168)(H,132,159)(H,133,147)(H,134,166)(H,135,164)(H,148,149)(H,150,151)(H,152,153)(H,170,171)(H4,111,112,115)(H4,113,114,116),(H,6,7)/t52-,53-,64+,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77+,86+,87+,88+,/m1./s1. InChi Key: CZDMBPXUDOGJGY-GEARQURQSA-N.