S7 (trifluoroacetate salt)

S7 is a peptide antagonist of the IL-6 receptor. It inhibits IL-6 binding to the IL-6 receptor in a concentration-dependent manner. S7 (50 µM) inhibits IL-6-induced increases in VEGF levels in C-33 A cervical cancer cells and RPMI-8226 B cell lymphocytes. It reduces tumor volume in an IL-6-overexpressing C-33 A cervical cancer mouse xenograft model when administered at a dose of 50 mg/kg every two days. When coupled to cysteine and the surface of lipid nanoparticles (LNPs) encapsulating doxorubicin, S7 increases LNP glioma targeting and increases survival in a U251 glioblastoma mouse xenograft model. Formal Name: L-leucyl-L-seryl-L-leucyl-L-threonyl-L-arginyl-L-leucine, trifluoroacetate salt. Synonyms: Leu-Ser-Leu-Iso-Thr-Arg-Leu-OH. Molecular Formula: C37H70N10O10 . XCF3COOH. Formula Weight: 815.0. Purity: >95%. Formulation: (Request formulation change), A solid. Peptide Sequence: LSLITRL-OH. Solubility: 1% HCOOH/H2O: Soluble. SMILES: OC(C(F)(F)F)=O.CC(C)C[C@H](N)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O)=O. InChi Code: InChI=1S/C37H70N10O10.C2HF3O2/c1-10-21(8)28(46-32(52)25(15-19(4)5)43-33(53)27(17-48)45-30(50)23(38)14-18(2)3)34(54)47-29(22(9)49)35(55)42-24(12-11-13-41-37(39)40)31(51)44-26(36(56)57)16-20(6)7,3-2(4,5)1(6)7/h18-29,48-49H,10-17,38H2,1-9H3,(H,42,55)(H,43,53)(H,44,51)(H,45,50)(H,46,52)(H,47,54)(H,56,57)(H4,39,40,41),(H,6,7)/t21-,22+,23-,24-,25-,26-,27-,28-,29-,/m0./s1. InChi Key: CGCUPVSMVDCCQB-GGLMJRKYSA-N.