PAR4 (1-6) amide (mouse) (trifluoroacetate salt)

PAR4 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 4 (PAR4) and an amide form of PAR4 (1-6) (Cay-27131) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse PAR4 and residues 60-65 of the full-length sequence. It induces aggregation of rat platelets with an EC50 value of 40 µM. PAR4 (1-6) amide (100 µM) induces smooth muscle relaxation and prostaglandin E2 (PGE2, Cay-14010) release in isolated mouse tracheal segments, effects that are inhibited by indomethacin (Cay-70270).Formal Name: glycyl-L-tyrosyl-L-prolylglycyl-L-lysyl-L-phenylalaninamide, trifluoroacetate salt. Molecular Formula: C33H46N8O7 . XCF3COOH. Formula Weight: 666.8. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: 1 mg/ml. SMILES: O=C(O)C(F)(F)F.NC([C@@H](NC([C@H](CCCCN)NC(CNC([C@@H]1CCCN1C([C@@H](NC(CN[H])=O)CC2=CC=C(O)C=C2)=O)=O)=O)=O)CC3=CC=CC=C3)=O. InChi Code: InChI=1S/C33H46N8O7.C2HF3O2/c34-15-5-4-9-24(31(46)40-25(30(36)45)17-21-7-2-1-3-8-21)38-29(44)20-37-32(47)27-10-6-16-41(27)33(48)26(39-28(43)19-35)18-22-11-13-23(42)14-12-22,3-2(4,5)1(6)7/h1-3,7-8,11-14,24-27,42H,4-6,9-10,15-20,34-35H2,(H2,36,45)(H,37,47)(H,38,44)(H,39,43)(H,40,46),(H,6,7)/t24-,25-,26-,27-,/m0./s1. InChi Key: KFRXPXZOFIFNOO-LQHVCSEWSA-N.