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You can also order by e-mail: info@biomol.com
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You can also order by e-mail: info@biomol.com
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Pam2CSK4 is a synthetic bacterial lipopeptide and an agonist of the toll-like receptor 2 (TLR2).... more
Product information "Pam2CSK4 (trifluoroacetate salt)"
Pam2CSK4 is a synthetic bacterial lipopeptide and an agonist of the toll-like receptor 2 (TLR2). It is selective for the TLR2/TLR6 heterodimer over TLR2/TLR1 (EC50s = 0.015 and 4.12 ng/ml, respectively, in reporter assays using human receptors). Pam2CSK4 increases the levels of inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO) in RAW 264.7 macrophages when used at a concentration of 100 ng/ml. It stimulates osteoclast formation, induces gingival inflammation, and decreases alveolar bone mass in a mouse model of periodontitis when administered at a dose of 5 µg/animal. Pam2CSK4 (10 µg/vaccine), when used as an adjuvant, reduces parasite burden and enhances the response to antigen, as measured by IgG levels, in a mouse model of lymphatic filariasis induced by B. malayi.Formal Name: S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-L-lysine, trifluoroacetate salt. Synonyms: Pam2Cys-Ser-(Lys)4. Molecular Formula: C65H126N10O12S . XCF3COOH. Formula Weight: 1271.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetic Acid (0.25%): 1 mg/ml. SMILES: CCCCCCCCCCCCCCCC(OC[C@@H](OC(CCCCCCCCCCCCCCC)=O)CSC[C@H](N)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(O)=O)CCCCN)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C65H126N10O12S.C2HF3O2/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-41-58(77)86-48-51(87-59(78)42-28-26-24-22-20-18-16-14-12-10-8-6-4-2)49-88-50-52(70)60(79)75-57(47-76)64(83)73-54(38-30-34-44-67)62(81)71-53(37-29-33-43-66)61(80)72-55(39-31-35-45-68)63(82)74-56(65(84)85)40-32-36-46-69,3-2(4,5)1(6)7/h51-57,76H,3-50,66-70H2,1-2H3,(H,71,81)(H,72,80)(H,73,83)(H,74,82)(H,75,79)(H,84,85),(H,6,7)/t51-,52+,53+,54+,55+,56+,57+,/m1./s1. InChi Key: WUCKUXUWRPCGSL-WJRQQJDCSA-N.
Keywords: | Pam2Cys-Ser-(Lys)4, S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-L-lysine, trifluoroacetate salt |
Supplier: | Cayman Chemical |
Supplier-Nr: | 33338 |
Properties
Application: | Bacterial lipopeptide, TLR2 agonist |
Conjugate: | No |
MW: | 1271.8 D |
Formula: | C65H126N10O12S . XCF3COOH |
Purity: | >98% |
Format: | Solid |
Database Information
KEGG ID : | K10159 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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