Pal-KTTKS (acetate)

Pal-KTTKS is a lipidated pentapeptide consisting of a fragment of the type I collagen C-terminal propeptide conjugated to palmitic acid (Cay-10006627). It increases collagen production in human corneal and dermal fibroblasts when used at concentrations of 0.002, 0.004, and 0.008 wt%. Following topical administration, pal-KTTKS (50 µg/cm2) is found in the stratum corneum, epidermis, and dermis of isolated hairless mouse skin. It can self-assemble into flat tapes and extended fibrillar structures. Pal-KTTKS has been detected in anti-wrinkle creams.Formal Name: N2-(1-oxohexadecyl)-L-lysyl-L-threonyl-L-threonyl-L-lysyl-L-serine, acetate. Synonyms: C16-KTTKS, Palmitoyl-KTTKS. Molecular Formula: C39H75N7O10 . XC2H4O2. Formula Weight: 802.1. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: Methanol: slightly soluble, Water: slightly soluble. SMILES: CCCCCCCCCCCCCCCC(N[C@H](C(N[C@@H]([C@@H](C)O)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CO)C(O)=O)=O)=O)[C@H](O)C)=O)=O)CCCCN)=O.CC(O)=O. InChi Code: InChI=1S/C39H75N7O10.C2H4O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-23-32(50)42-29(21-17-19-24-40)36(52)45-34(28(3)49)38(54)46-33(27(2)48)37(53)43-30(22-18-20-25-41)35(51)44-31(26-47)39(55)56,1-2(3)4/h27-31,33-34,47-49H,4-26,40-41H2,1-3H3,(H,42,50)(H,43,53)(H,44,51)(H,45,52)(H,46,54)(H,55,56),1H3,(H,3,4)/t27-,28-,29+,30+,31+,33+,34+,/m1./s1. InChi Key: LGKXAOUSDAHKDF-VIKHUJRRSA-N.