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NF-kappaB inhibitor (Cay-17493) is a synthetic peptide corresponding to the nuclear localization sequence (NLS) of NF-kappaB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells. It blocks the nuclear import of p105 in cells treated with activators of NF-kappaB signaling, including LPS and TNF-alpha. NF-kappaB control is a peptide that is identical in sequence to NF-kappaB inhibitor, except two essential, basic residues of the p105 NLS are substituted with non-basic amino acids. It is ineffective at blocking the activation of NF-kappaB signaling and is used as a negative control peptide.CAS Number: 201608-17-5. Synonyms: SN50M. Molecular Formula: C123H215N33O30S. Formula Weight: 2668.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 10 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: [H]N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N1CCC[C@H]1C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(N2CCC[C@H]2C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O). InChi Code: InChI=1S/C123H215N33O30S/c1-59(2)50-80(146-112(175)85(55-64(11)12)149-118(181)96(67(17)18)152-102(165)73(25)135-114(177)88-36-32-47-155(88)121(184)87(56-65(13)14)150-113(176)83(53-62(7)8)144-100(163)71(23)136-116(179)95(66(15)16)151-101(164)72(24)133. InChi Key: NAOYXUUPTUDXHE-YQTWEEOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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