CTDSP1, Recombinant, Human, aa1-260, His-tag (Carboxy-terminal Domain RNA Polymerase II Polypeptide

CTDSP1, Recombinant, Human, aa1-260, His-tag (Carboxy-terminal Domain RNA Polymerase II Polypeptide
Item number Size Datasheet Manual SDS Delivery time Quantity Price
C7947-98F.50 50 µg - -

1 - 19 business days

519.00€
 
Carboxy-terminal domain, RNA polymerase II, polypeptide A phosphatase 1, also known as CTDSP1, is... more
Product information "CTDSP1, Recombinant, Human, aa1-260, His-tag (Carboxy-terminal Domain RNA Polymerase II Polypeptide"
Carboxy-terminal domain, RNA polymerase II, polypeptide A phosphatase 1, also known as CTDSP1, is a class 2C phosphatase with activity dependent on the conserved DxD motif. CTDSP1 preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Also it negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Source: Recombinant corresponding to aa1-260 from human CTDSP1, fused to His-tag at N-terminus expressed in E.coli. AA Sequence: MGSSHHHHHH SSGLVPRGSH MDSSAVITQI SKEEARGPLR GKGDQKSAAS QKPRSRGILH SLFCCVCRDD GEALPAHSGA PLLVEENGAI PKTPVQYLLP EAKAQDSDKI CVVIDLDETL HSSFKPVNN ADFIIPVEID GVVHQVYVLK RPHVDEFLQR MGELFECVLF TASLAKYADP VADLLDKWGA FRARLFRESC VFHRGNYVKD LSRLGRDLRR VLILDNSPAS YVFHPDNAVP VASWFDNMSD TELHDLLPFF EQLSRVDDVY SVLRQPRPGS, Molecular Weight: ~31.2kD (280aa), confirmed by MALDI-TOF, Enzyme Activity: Not determined. This product is recommended for use in applications that do not require a catalytically active form of the protein. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: SCP1, EC=3.1.3.16, Small CTD phosphatase 1, NLI-interacting factor 3, Small C-terminal domain phosphatase 1, Nuclear LIM interactor-interacting factor 3, Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Supplier: United States Biological
Supplier-Nr: C7947-98F

Properties

Conjugate: No
MW: 31,2 kD
Format: Highly Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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