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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay37626-1 | 1 mg | - |
6 - 10 business days* |
300.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Citrullinated histone H3 (R2 + R8 + R17) (2-22)-biotin peptide is a biotinylated version of... more
Product information "Citrullinated Histone H3 (R2 + R8 + R17) (2-22)-biotin Peptide"
Citrullinated histone H3 (R2 + R8 + R17) (2-22)-biotin peptide is a biotinylated version of tri-citrullinated histone H3, a nuclear protein that interacts with linker DNA regions between nucleosomes to provide nucleosome core structure stabilization. Histone H3 is subject to citrullination by protein-arginine deiminase 4 (PAD4) at arginine 2 (R2), R8, and R17 during neutrophil extracellular trap formation (NETosis). Citrullination of histone H3 at these residues reduces the positive charge of histone H3 and leads to decondensed chromatin, which is expelled into the extracellular space when the neutrophil membrane ruptures. Increased serum levels of histone H3 citrullinated at R2, R8, and R17 have been found in patients with asthma and in septic shock patients where they are positively associated with a sequential organ failure assessment (SOFA) score and poor survival. Sputum levels of histone H3 citrullinated at R2, R8, and R17 are increased in patients with rheumatoid arthritis, as well as in individuals identified as at risk for developing rheumatoid arthritis based on their seropositivity for IgA anti-citrullinated protein antibodies (ACPAs). Cayman's Citrullinated Histone H3 (R2 + R8 + R17) (2-22)-biotin Peptide is intended for use in the detection of autoantibodies against histone H3 citrullinated at R2, R8, and R17.Synonyms: Biotin-A-Cit-TKQTA-Cit-KSTGGKAP-Cit-KQLA, Biotin-AXTKQTAXKSTGGKAPXKQLA (X=Citrulline), Citrullinated Histone H3.1-biotin. Formulation: (Request formulation change), 1 mg of lyophilized peptide. UniProt Accession #: P68431.
Keywords: | Biotin-A-Cit-TKQTA-Cit-KSTGGKAP-Cit-KQLA, Biotin-AXTKQTAXKSTGGKAPXKQLA (X=Citrulline), Citrullinated Histone H3.1-biotin |
Supplier: | Cayman Chemical |
Supplier-Nr: | 37626 |
Properties
Application: | Biotinylated & citrullinated histone H3 peptide |
Conjugate: | Biotin |
Format: | Lyophilized |
Database Information
KEGG ID : | K11253 | Matching products |
UniProt ID : | P68431 | Matching products |
Gene ID | GeneID 8350 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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