Amyloid-beta (25-35) Peptide (human) (trifluoroacetate salt)

Amyloid-beta (25-35) (Abeta (25-35)) is an 11-residue fragment of the Abeta protein that retains the physical and biological characteristics of the full length peptide. It forms fibrils that react to thioflavin T and Congo red and are organized in a cross-beta arrangement of beta-strands similar to Abeta (1-40) (Cay-21617) and Abeta (1-42) (Cay-20574) fibrils. Aggregated Abeta (25-35) decreases the viability of rat adrenal PC12 cells. It also decreases the viability of primary rat cortical neurons at concentrations ranging from 1 nM to 30 µM. In vivo, intracerebral injection of Abeta (25-35) (20 nmol) in rats induces lesions of neuronal and tissue loss. Aggregated Abeta (25-35) administered intracerebroventricularly to rats induces learning and memory impairments in the Y-maze, novel object recognition, and contextual fear conditioning tests.Formal Name: glycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionine, trifluoroacetate salt. Synonyms: Abeta (25-35). Molecular Formula: C45H81N13O14S . XCF3COOH. Formula Weight: 1060.3. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Water: 1 mg/ml. SMILES: O=C([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(CN)=O)CO)=O)CC(N)=O)=O)CCCCN)=O)=O)C)=O)[C@H](CC)C)N[C@H](C(NCC(N[C@H](C(N[C@@H](CCSC)C(O)=O)=O)CC(C)C)=O)=O)[C@H](CC)C.FC(F)(C(O)=O)F. InChi Code: InChI=1S/C45H81N13O14S.C2HF3O2/c1-9-24(5)36(43(69)50-21-35(63)52-29(17-23(3)4)40(66)55-28(45(71)72)14-16-73-8)58-44(70)37(25(6)10-2)57-38(64)26(7)51-34(62)20-49-39(65)27(13-11-12-15-46)54-41(67)30(18-32(48)60)56-42(68)31(22-59)53-33(61)19-47,3-2(4,5)1(6)7/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,69)(H,51,62)(H,52,63)(H,53,61)(H,54,67)(H,55,66)(H,56,68)(H,57,64)(H,58,70)(H,71,72),(H,6,7)/t24-,25-,26-,27-,28-,29-,30-,31-,36-,37-,/m0./s1. InChi Key: ALHHDLMFVTWOLX-BZDKSGIQSA-N.