Amyloid-beta (22-35) Peptide (trifluoroacetate salt)

Amyloid-beta (Abeta) (22-35) is a 13-residue fragment of Abeta that corresponds to residues 693-705 of the human amyloid precursor protein (APP) full-length sequence. It assembles straight fibrils and bundles that bind thioflavin T in vitro. Abeta (22-35) (40 µg/ml) induces cell death in rat hippocampal neurons.Formal Name: L-alpha-glutamyl-L-alpha-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionine, trifluoroacetate salt. Synonyms: Abeta (22-35). Molecular Formula: C59H102N16O21S . XCF3COOH. Formula Weight: 1403.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Formic Acid: 1 mg/ml. SMILES: O=C(O)C(F)(F)F.[H]N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(NCC(N[C@H](C(N[C@]([C@H](CC)C)([H])C(N[C@]([C@H](CC)C)([H])C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)CCSC)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)CC(O)=O)=O. InChi Code: InChI=1S/C59H102N16O21S.C2HF3O2/c1-11-30(7)47(57(93)65-25-42(79)67-36(21-28(3)4)52(88)70-35(59(95)96)18-20-97-10)75-58(94)48(31(8)12-2)74-49(85)32(9)66-41(78)24-63-51(87)34(15-13-14-19-60)69-53(89)37(22-40(62)77)72-55(91)39(27-76)68-43(80)26-64-56(92)46(29(5)6)73-54(90)38(23-45(83)84)71-50(86)33(61)16-17-44(81)82,3-2(4,5)1(6)7/h28-39,46-48,76H,11-27,60-61H2,1-10H3,(H2,62,77)(H,63,87)(H,64,92)(H,65,93)(H,66,78)(H,67,79)(H,68,80)(H,69,89)(H,70,88)(H,71,86)(H,72,91)(H,73,90)(H,74,85)(H,75,94)(H,81,82)(H,83,84)(H,95,96),(H,6,7)/t30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,46-,47-,48-,/m0./s1. InChi Key: KCXLLHVWIBOFKL-KPRPSXLASA-N.