(Ala1)-PAR4 (1-6) (mouse) (trifluoroacetate salt)

(Ala1)-PAR4 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 4 (PAR4) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse PAR4 and residues 60-65 of the full-length sequence with an alanine residue substituted for glycine at position 1/60. It is 10-fold more potent than PAR4 (1-6) (Cay-27131), triggering [3H]inositol phosphate release from KOLF cells expressing human PAR4 at levels comparable to 30 nM thrombin (Cay-13188) when used at a concentration of 500 µM. (Ala1)-PAR4 (1-6) induces aggregation of human platelets.Formal Name: L-alanyl-L-tyrosyl-L-prolylglycyl-L-lysyl-L-phenylalanine, trifluoroacetate salt. Synonyms: H-Ala-Tyr-Pro-Gly-Lys-Phe-OH, AYPGKF. Molecular Formula: C34H47N7O8 . XCF3COOH. Formula Weight: 681.8. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: 1 mg/ml. SMILES: OC(C(F)(F)F)=O.[H]N[C@H](C(N[C@H](C(N1CCC[C@H]1C(NCC(N[C@@H](CCCCN)C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)CC3=CC=C(O)C=C3)=O)C. InChi Code: InChI=1S/C34H47N7O8.C2HF3O2/c1-21(36)30(44)39-26(18-23-12-14-24(42)15-13-23)33(47)41-17-7-11-28(41)32(46)37-20-29(43)38-25(10-5-6-16-35)31(45)40-27(34(48)49)19-22-8-3-2-4-9-22,3-2(4,5)1(6)7/h2-4,8-9,12-15,21,25-28,42H,5-7,10-11,16-20,35-36H2,1H3,(H,37,46)(H,38,43)(H,39,44)(H,40,45)(H,48,49),(H,6,7)/t21-,25-,26-,27-,28-,/m0./s1. InChi Key: XCJYZEYUJMUFTI-HKJXYENISA-N.