A11 (trifluoroacetate salt)

A11 is a cell-penetrating peptide composed of the HIV-1 Tat protein transduction domain linked to an 11-amino acid peptide corresponding to residues 20-30 of the annexin A1 N-terminus. It decreases annexin A1 binding to Eph receptor tyrosine kinase A2 (EphA2) and increases EphA2 ubiquitination in HK1 nasopharyngeal carcinoma (NPC) cells. A11 (10 µM) inhibits HK1 and 5-8F NPC cell proliferation, migration, and invasion. In vivo, A11 reduces tumor volume in 5-8F and HK1 NPC mouse xenograft models.Formal Name: L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-alpha-glutamyl-L-tyrosyl-L-valyl-L-glutaminyl-L-threonyl-L-valyl-L-lysyl-L-seryl-L-seryl-L-lysyl-glycine, trifluoroacetate salt. Synonyms: CPP-EYVQTVKSSKG. Molecular Formula: C117H204N46O32 . XCF3COOH. Formula Weight: 2767.2. Purity: >95%. Formulation: (Request formulation change), A solid. Peptide Sequence: YGRKKRRQRRREYVQTVKSSKG-OH. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 2 mg/ml. SMILES: OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC([C@H](CCC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC(CNC([C@@H](N)CC2=CC=C(C=C2)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C117H204N46O32.C2HF3O2/c1-60(2)89(109(193)157-79(39-42-85(124)170)105(189)163-91(62(5)166)111(195)162-90(61(3)4)110(194)156-72(23-9-13-47-121)102(186)159-83(59-165)108(192)160-82(58-164)107(191)146-68(20-6-10-44-118)93(177)144-57-88(174)175)161-106(190)81(55-64-32-36-66(168)37-33-64)158-104(188)80(40-43-87(172)173)155-101(185)77(29-19-53-142-117(135)136)152-98(182)74(26-16-50-139-114(129)130)150-99(183)75(27-17-51-140-115(131)132)153-103(187)78(38-41-84(123)169)154-100(184)76(28-18-52-141-116(133)134)151-97(181)73(25-15-49-138-113(127)128)149-96(180)71(22-8-12-46-120)148-95(179)70(21-7-11-45-119)147-94(178)69(24-14-48-137-112(125)126)145-86(171)56-143-92(176)67(122)54-63-30-34-65(167)35-31-63,3-2(4,5)1(6)7/h30-37,60-62,67-83,89-91,164-168H,6-29,38-59,118-122H2,1-5H3,(H2,123,169)(H2,124,170)(H,143,176)(H,144,177)(H,145,171)(H,146,191)(H,147,178)(H,148,179)(H,149,180)(H,150,183)(H,151,181)(H,152,182)(H,153,187)(H,154,184)(H,155,185)(H,156,194)(H,157,193)(H,158,188)(H,159,186)(H,160,192)(H,161,190)(H,162,195)(H,163,189)(H,172,173)(H,174,175)(H4,125,126,137)(H4,127,128,138)(H4,129,130,139)(H4,131,132,140)(H4,133,134,141)(H4,135,136,142),(H,6,7)/t62-,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77+,78+,79+,80+,81+,82+,83+,89+,90+,91+,/m1./s1. InChi Key: AIXWXLBINOGQOS-SAAIPHAHSA-N.