Other Peptides

Aspartyl-alanyl-diketopiperazine is an immunosuppressive diketopiperazine derivative of a human serum albumin (HSA) peptide. It reduces antigen-induced TNF-alpha and IFN-gamma production in isolated human T cells when used at a concentration of 500 µM.Formal Name: 5S-methyl-3,6-dioxo-2S-piperazineacetic acid. CAS...

SAP15 is a cell-penetrating peptide consisting of the C-terminal amino acids 52-67 of human beta-defensin-3 (Cay-24578).Formal Name: glycyl-L-lysyl-L-cysteinyl-L-seryl-L-threonyl-L-arginylglycyl-L-arginyl-L-lysyl-L-cysteinyl-L-cysteinyl-L-arginyl-L-arginyl-L-lysyl-L-lysine, trifluoroacetate salt. Synonyms: Synthetic...

Fmoc-Thr(GalNAc(Ac)3-alpha-D)-OH is a building block. It has been used in the synthesis of antibacterial glycopeptides and anticancer glycopeptide vaccines.Formal Name: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-alpha-D-galactopyranosyl]-L-threonine. CAS Number: 116783-35-8....

GR94800 is a synthetic peptide neurokinin-2 (NK2) receptor antagonist (Ki = 1 nM). It is selective for NK2 over NK3 (Ki = 1,000 nM). GR94800 (0.1 and 1 µM) decreases balloon distension-induced submaximal and maximal atropine-resistant ascending excitatory reflex (AER) in isolated guinea pig ileum circular...

HCKFWW is a thiol-containing peptide and form of the HIV-1 integrase inhibitor HCKFWW-NH2. It has been used as an analyte in the development of zirconium nanoparticles as probes and matrices for mass spectrometry applications.Formal Name: L-histidyl-L-cysteinyl-L-lysyl-L-phenylalanyl-L-tryptophyl-L-tryptophan,...

D-Ala-D-Ala is the terminal dipeptide moiety of peptidoglycan in bacterial cell walls and a target of certain antibacterial agents. Replacement of D-Ala-D-Ala with D-Ala-D-lactate by the combined activity of the enterococcal gene products VanA, VanH, and VanX reduces the affinity of the antibiotic vancomycin...

M40 is a chimeric galanin-derived peptide and galanin-1 (GAL1) receptor antagonist and GAL2 receptor agonist (Kis = 2.4 and 4.07 nM, respectively). It is selective for the GAL1 and GAL2 receptors over the GAL3 receptor (Ki = 288 nM). M40 induces inositol phosphate accumulation in CHO cells expressing the human GAL2...

Lixisenatide is an agonist of glucagon-like peptide 1 receptor (GLP-1R) and a derivative of exendin-4 (48-86) amide (Cay-11096). It binds to CHO-K1 cells expressing human GLP-1R (IC50 = 1.4 nM). Lixisenatide (100 pM) inhibits Il-1beta- and IFN-gamma-induced apoptosis in INS-1 rat pancreatic beta-cells. It lowers...

Mastoparan 7 is a G protein activator and derivative of the mast cell degranulating peptide mastoparan (Cay-20240). It decreases the affinity of acetylcholine (ACh) to porcine brain muscarinic ACh receptors (mAChRs) when used at a concentration of 30 µM and induces GDP/GTP exchange by Gi in a concentration-dependent...

L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4+ and CD8+ T lymphocytes without affecting helper T cells and B cells. It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid...

Z-VAD(OMe)-FMK is a cell-permeable, competitive, and irreversible inhibitor of all caspases. Through this action, it inhibits cleavage of poly(ADP-ribose) polymerase, preventing apoptosis when used at 10-50 µM. It also blocks caspase-mediated apoptosis in vivo. Z-VAD(OMe)-FMK effectively prevents caspase action in...

Peptide YY (PYY) is a polypeptide that is released postprandially in proportion to meal energy content by endocrine L cells in the ileum and colon in order to regulate appetite. PYY, along with neuropeptide Y (NPY, Cay-15071), inhibits gastrointestinal motility and electrolyte secretion, which is thought to indicate...