IGFBP5 Blocking Peptide

IGFBP5 is a secreted protein that is a critical member of the IGF axis. It binds IGF-1 and restricts it from accessing its cell-surface receptor (IGF-1R). This aids in regulation of cell growth, differentiation, and apoptosis. IGFBP5 also displays IGF-1 independent transactivational activity in the nucleus. Some tissues and cell types with higher levels of this protein include kidney, heart, placenta, and skeletal cells. Expression has also been reported in a variety of cancers, including mammary gland and neuroblastoma. IGFBP5 (272 amino acids) has a calculated molecular weight of 30.6 kDa. Reported glycosylation and phosphorylation sites may explain the band migration to 33 kDa. Cayman's IGFBP5 polyclonal antibody is directed against a synthetic peptide sequence that partially overlaps the IGFBP5 region identified as a nuclear localization signal.Formal Name: 200 µg peptide in 200 µl TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide. Synonyms: Insulin-Like Growth Factor-Binding Protein 5 Blocking Peptide, IBP-5 Blocking Peptide, IGF-Binding Protein 5 Blocking Peptide. Formulation: (Request formulation change), 200 µg of peptide in 200 µl of TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide.