Peptides

NucView(R) 530 Caspase-3 Substrate, 1 mM in PBS, provides a convenient tool for detecting apoptosis in intact cells based on caspase-3/7 activity using either confocal microscopy or flow cytometry. In contrast to other fluorogenic caspase substrates or fluorescent caspase inhibitor based (FLICA) assays, NucView(R)...

Tat-Gap 19 is a peptide inhibitor of connexin43 (Cx43) hemichannels. It is composed of the HIV-1 Tat protein transduction domain linked to a nine-amino acid peptide corresponding to residues 128-136 of Cx43. Tat-Gap 19 (10 µM) inhibits glutamate-induced ATP release, a marker of Cx43 hemichannel activity, in primary...

Exendin-4 (3-39) amide is an agonist of glucagon-like peptide 1 receptor (GLP-1R) and an active metabolite of exendin-4 (48-86) amide (Cay-11096). It is formed from exendin-4 (48-86) amide in rat liver homogenates. Exendin-4 (3-39) amide induces cAMP accumulation in HEK293 cells expressing human GLP-1R (EC50 = 9...

Fz7-21 is a peptide antagonist of the frizzled family G protein-coupled receptor 7 (FZD7, IC50 = 100 nM). It inhibits Wnt3a-induced beta-catenin signaling in a reporter assay using HEK293 cells. Fz7-21 (100 µM) reduces the number of cells positive for leucine-rich alpha-2-glycoprotein 5 (Lrg5), a marker of...

F9170 is an antiviral peptide corresponding to amino acids 789-803 of the HIV-1 envelope glycoprotein. It binds to the LLP1 domain within the HIV-1 envelope protein cytoplasmic tail and inhibits HIV-1 IIIB infection of MT-2 cells (EC50 = 0.19 µM). F9170 (3 mg/kg) reduces plasma viral load in a rhesus macaque model...

Wasabi receptor toxin (WaTx) (36-68) is a cell-penetrating peptide that corresponds to the mature toxin sequence and is an activator of transient receptor potential ankyrin 1 (TRPA1). It selectively induces currents in HEK293T cells expressing human TRPA1 (EC50 = 15 nM) over cells expressing human TRP melastatin 8...

RS repeat peptide is a serine/arginine-rich peptide substrate for CDC-like kinase 1 (Clk1). It has been used to identify inhibitors of Clk1 with anticancer activity.Formal Name:...

Tat-ASIC1a (1-20) is a synthetic peptide composed of the cell-penetrating peptide sequence from the HIV-1 Tat protein transduction domain linked to a 20-amino acid peptide corresponding to amino acids 1-20 of acid-sensing ion channel 1a (ASIC1a). It prevents acid-induced association of ASIC1a with...

Fyn peptide (410-430) is a peptide fragment of the Src family non-receptor tyrosine kinase Fyn containing Tyr420, which undergoes autophosphorylation upon activation of full-length Fyn.Formal Name:...

Aspartyl-alanyl-diketopiperazine is an immunosuppressive diketopiperazine derivative of a human serum albumin (HSA) peptide. It reduces antigen-induced TNF-alpha and IFN-gamma production in isolated human T cells when used at a concentration of 500 µM.Formal Name: 5S-methyl-3,6-dioxo-2S-piperazineacetic acid. CAS...

SAP15 is a cell-penetrating peptide consisting of the C-terminal amino acids 52-67 of human beta-defensin-3 (Cay-24578).Formal Name: glycyl-L-lysyl-L-cysteinyl-L-seryl-L-threonyl-L-arginylglycyl-L-arginyl-L-lysyl-L-cysteinyl-L-cysteinyl-L-arginyl-L-arginyl-L-lysyl-L-lysine, trifluoroacetate salt. Synonyms: Synthetic...

Fmoc-Thr(GalNAc(Ac)3-alpha-D)-OH is a building block. It has been used in the synthesis of antibacterial glycopeptides and anticancer glycopeptide vaccines.Formal Name: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-alpha-D-galactopyranosyl]-L-threonine. CAS Number: 116783-35-8....