TPO, Swine

Sequence: APPRLICDSR VLERYILEAK EGENATMGCA ESCSFSENIT VPDTKVNFYA WKRMEVQQQA MEVWQGLALL SEAILQGQAL LANSSQPSEA LHVDKAVSGL RSLTSLLRAL GAQKEAIPLP DASPSSATPL RTFAVDTLCK LFRNYSNFLR GKLTLYTGEA with polyhistidine tag at the N-terminus Endotoxin level: <0.1 EU per 1 µg of the protein by the LAL method. Protein function: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. [The UniProt Consortium]