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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay40212-50 | 50 µg | - | - |
6 - 10 business days* |
319.00€
|
||
Cay40212-1 | 1 mg | - | - |
6 - 10 business days* |
3,186.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Fas ligand (FasL), also known as CD95L, is a type II transmembrane protein and member of the TNF... more
Product information "Soluble Fas Ligand/CD95 Ligand (human, recombinant, aa 134-281)"
Fas ligand (FasL), also known as CD95L, is a type II transmembrane protein and member of the TNF superfamily. It is composed of a cytoplasmic domain, transmembrane domain, stalk region, TNF homology domain (THD), which is involved in homotrimerization, and Fas-binding domain. FasL is expressed in activated T cells, as well as the placenta, testis, lung, prostate, esophagus, uterus and spleen. Binding of FasL to its receptor Fas leads to formation of a death-inducing signaling complex (DISC) composed of CD95 oligomers, the Fas-associated death domain protein (FADD), and procaspase-8, procaspase-10, and cellular FLICE-like inhibitory protein (c-FLIP), which induces apoptosis. Soluble FasL (sFasL) is produced by proteolytic cleavage of FasL by various matrix metalloproteinases (MMPs) and either inhibits FasL-induced apoptosis or induces apoptosis in a context-dependent manner. sFasL induces migration of isolated human neutrophils and apoptosis in primary human distal lung epithelial cells. It decreases ankylosis in a rat model of collagen-induced arthritis. Serum levels of sFasL are increased in patients with insulin-dependent diabetes mellitus, systemic lupus erythematosus (SLE), rheumatoid arthritis, gastric cancer, or leukemia. Cayman's Soluble Fas Ligand/CD95 Ligand (human, recombinant, aa 134-281) protein can be used for binding assays. This protein consists of 168 amino acids and has a calculated molecular weight of 19.3 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 26 kDa due to glycosylation.Synonyms: CD178, CD95L, FasL, FASLG, TNFL6, TNF Ligand Superfamily Member 6, TNFSF6, Tumor Necrosis Factor Ligand 6. Purity: >90% estimated by SDS-PAGE. Source: Active recombinant human N-terminal His-tagged FasL expressed in yeast. Amino Acids: 134-281. MW: 19.3 KDa. Formulation: (Request formulation change), Lyophilized from sterile PBS, pH 7.4. UniProt Accession #: P48023.
Keywords: | APL, SPA, APTL, FasL, FASLG, CD178, sFasL, CD95-L, APT1LG1, FasL ICD, Fas ligand, CD95 ligand, Fas antigen ligand, Soluble Fas ligand, Apoptosis antigen ligand, FasL intracellular domain, ADAM10-processed FasL form, SPPL2A-processed FasL form, Receptor-bi |
Supplier: | Cayman Chemical |
Supplier-Nr: | 40212 |
Properties
Application: | Active |
Conjugate: | No |
Purity: | >90% estimated by SDS-PAGE |
Format: | Lyophilized |
Database Information
KEGG ID : | K04389 | Matching products |
UniProt ID : | P48023 | Matching products |
Gene ID | GeneID 356 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | -80°C (International: -80°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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