Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. (www.uniprot.org) Human recombinant sCD40 produced in E.coli is a single, non-glycosylated, polypeptide chain containing 149 amino acids fragment (113-261) corresponding to the receptor binding domain of the sCD40L protein, having a molecular weight of 21.5kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. CD40L or CD154 is a membrane glycoprotein and differentiation antigen expressed on the surface of T-cells. The CD40 ligand stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also costimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL-2.
|Keywords:||CD40-L, Tumor necrosis factor ligand superfamily member 5, TNF-related activation protein, TRAP, T cell antigen Gp39, CD154 antigen, sCD40, IGM, IMD3, HIGM1, T-BAM, TNFSF5, hCD40L, CD40LG|
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