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Human recombinant HB-EGF produced in E.coli is a single, non-glycosylated, polypeptide chain containing 86 amino acids and having a molecular mass of 9.7kDa. HB-EGF is an EGF related growth factor which signals via the EGF receptor, and stimulates the proliferation of SMC (smooth muscle cells), fibroblasts, epithelial cells and keratinocytes. HB-EGF is expressed in various cell types and tissues, including vascular endothelial cells and SMC, macrophages, skeletal muscle, keratinocytes and particular tumor cells. HB-EGF's ability to explicitly bind heparin and heparin sulfate proteoglycans is dissimilar from other EGF-like molecules, and might be related to the enhanced mitogenic activity, relative to EGF, that HB-EGF exerts on smooth muscle cells.
Keywords: | Proheparin-binding EGF-like growth factor, HBEGF, DTR, DTS, HEGFL, HB-EGF, Heparin-binding EGF-like growth factor, Diphtheria toxin receptor, DT-R, DTSF. |
Supplier: | Biomol GmbH |
Supplier-Nr: | 97560.1 |
Properties
Application: | Cell Culture |
Conjugate: | No |
Expressed in: | E.coli |
Origin: | Human |
MW: | 97000 D |
Purity: | >97% |
Format: | Lyophilized |
Database Information
KEGG ID : | K08523 | Find alternatives |
UniProt ID : | Q99075 | Find alternatives |
Gene ID | GeneID 1839 | Find alternatives |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Our products are for laboratory research use only: Not for administration to humans!