Mesencephalic Astrocyte-Derived Neurotrophic Factor, His Tag, human recombinant (rHuMANF-His)

Human recombinant MANF produced in E.coli is a single polypeptide chain containing 183 amino acids (25-182) and having a molecular mass of 20.8kDa. MANF is fused to a 25 amino acid His-tag at N-terminus. MANF is a 20kDa protein which belongs to the ARMET family. MANF was originally known as an arginine-rich region protein which was extremely mutated in a large number of tumors. MANF Expression is induced during ER stress, signifying that MANF takes part in protein quality control during ER stress.