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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-PKSH031989.20 | 20 µg | - |
7 - 16 business days* |
388.00€
|
|||
E-PKSH031989.100 | 100 µg | - |
7 - 16 business days* |
948.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Activity: Measured by its ability to inhibit the proliferation of M1 mouse myeloid leukemia... more
Product information "LIF Protein (recombinant human)"
Activity: Measured by its ability to inhibit the proliferation of M1 mouse myeloid leukemia cells.The ED50 for this effect is typically 0.2-0.8 ng/mL. Protein Construction: A DNA sequence encoding the human LIF (P15018) (Met1-Phe202) was expressed. Sequence: Met 1-Phe202. Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 35.4 kDa. Protein function: Leukemia inhibitory factor (LIF) is a pleiotropic glycoprotein belonging to the IL-6 family of cytokines. It's involved in growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation. LIF has potent proinflammatory property, being the inducer of the acute phase protein synthesis and affecting the cell recruitment into the area of damage or inflammation. LIF is also one of the cytokines that are capable to regulate the differentiation of embryonic stem cells, hematopoietic and neuronal cells. LIF binds to the specific LIF receptor (LIFR-alpha) which forms a heterodimer with a specific subunit common to all members of that family of receptors, the GP130 signal transducing subunit. This leads to activation of the JAK/STAT and MAPK cascades. Due to its polyfunctional activities, LIF is involved in the pathogenic events and development of many diseases of various origin. Protein function: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes. [The UniProt Consortium]
Keywords: | LIF, MLPLI, HILDA, D factor, Emfilermin, Leukemia inhibitory factor, Melanoma-derived LPL inhibitor, Differentiation-stimulating factor, Recombinant Human LIF Protein |
Supplier: | Elabscience |
Supplier-Nr: | E-PKSH031989 |
Properties
Conjugate: | No |
Host: | Human cells |
Species reactivity: | human |
MW: | 19.7 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K05419 | Matching products |
UniProt ID : | P15018 | Matching products |
Gene ID | GeneID 3976 | Matching products |
Handling & Safety
Storage: | -80°C |
Shipping: | +4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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