LEC/NCC-4 (CCL16), human recombinant (rHuCCL16)

LEC/NCC-4 (CCL16), human recombinant (rHuCCL16)
Please request pricing for this article.
Request Pricing

Item number Size Datasheet Manual SDS Delivery time Quantity Price
97326.5 5 µg - -

3 - 10 business days*

71.00€
97326.20 20 µg - -

3 - 10 business days*

184.00€
97326.1 1 mg - -

3 - 10 business days*

-
 
Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent... more
Product information "LEC/NCC-4 (CCL16), human recombinant (rHuCCL16)"

Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES. (www.uniprot.org) Recombinant human CCL16 produced in E.coli is a non-glycosylated, polypeptide chain containing 97 amino acids and having a molecular mass of 11.2 kDa. Human CCL16, also called HCC-4, liver-expressed chemokine (LEC), and lymphocyte and monocyte chemoattractant (LMC), is a novel CC chemokine recognized by bioinformatics. NCC-4 cDNA encodes a 120 amino acids along with a 23 amino acids signal peptide that is cleaved to generate 97 amino acid protein. HCC4 is vaguely related to other CC chemokines, showing less than 30% sequence identity. Among CC chemokines, CCL-16 has the largest similarity to HCC-1. 2 potential polyadenylation signals are present on the human HCC-4 gene, and as a result, 2 transcripts containing roughly 1,500 base pairs and 500 base pairs have been detected. HCC-4 is expressed weakly by some lymphocytes, including NK cells, T cells, and some T cell clones. The expression of HCC-4 in monocytes is greatly upregulated in the presence of IL-10. CCL16 shows chemotactic activity for lymphocytes and monocytes rather than to neutrophils. NCC-4 has potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. CCL16 demonstrates chemotactic activity for monocytes and thp-1 monocytes, rather than for resting lymphocytes and neutrophils. HCC-4 induces a calcium flux in thp-1 cells that desensitized prior to the expression of rantes.

Keywords: C-C motif chemokine 16, Small-inducible cytokine A16, IL-10-inducible chemokine, Chemokine LEC, Monotactin-1, Chemokine CC-4, Lymphocyte and monocyte chemoattractant, CCL-16, HCC-4, HCC4, NCC4, NCC-4, Liver Expressed Chemokine, LMC, LCC-1, LCC1, MTN-1, MT
Supplier: Biomol GmbH
Supplier-Nr: 97326

Properties

Application: Cell culture
Conjugate: No
Expressed in: E.coli
Origin: Human
MW: 11200 D
Format: Purified

Database Information

KEGG ID : K21093 | Find alternatives
UniProt ID : O15467 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow. more
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "LEC/NCC-4 (CCL16), human recombinant (rHuCCL16)"
Write a review
or to review a product.
Viewed