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Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. (www.uniprot.org) Produced in E.coli as a single, non-glycosylated, polypeptide chain containing 129 amino acids (fragment 25-153) with an amino-terminal hexahistidine tag.
|Keywords:||BCGF, BCDF, B cell stimulating factor, BSF-1, Lymphocyte stimulatory factor 1, IL-4, MGC79402, Binetrakin, Pitrakinra|
|Application:||Cell biology studies|
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