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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
AG-40B-0097-C010 | 10 µg | - |
3 - 9 business days* |
171.00€
|
|||
AG-40B-0097-3010 | 30 µg (3 x 10 ug) | - |
3 - 9 business days* |
341.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
IL36Ra (human) (aa 2-155) is untagged. Can be used for inhibition of biological activity of... more
Product information "Interleukin-36 Receptor Antagonist, (IL-36Ra) (human, rec.) - 3 x 10 µg"
IL36Ra (human) (aa 2-155) is untagged. Can be used for inhibition of biological activity of IL-36. IL-36Ra/IL-1F5 is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9). These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are target of the IL-36 interleukins leading to a Th1 response. Recently mutations that affect the levels and the activity of IL-36Ra have been found in patients with pustular psoriasis, leading to enhanced production of inflammatory cytokines (IL-8 in particular) by keratinocytes.
Keywords: | FIL1D, IL36RN, IL-1F5, IL-1L1, IL-1RP3, IL-1HY1, FIL1 delta, IL-1 delta, IL-1ra homolog 1, Interleukin-1 HY1, Interleukin-1 delta, IL-1-related protein 3, Interleukin-1-like protein 1, Interleukin-1 family member 5 |
Supplier: | AdipoGen Life Sciences |
Supplier-Nr: | AG-40B-0097 |
Properties
Application: | IL-36 inhibition |
Conjugate: | No |
Host: | E.coli |
Species reactivity: | human |
MW: | 17 kD |
Purity: | >95% |
Database Information
KEGG ID : | K05483 | Matching products |
UniProt ID : | Q9UBH0 | Matching products |
Gene ID | GeneID 26525 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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