Interleukin-36 receptor antagonist, active (IL36RN), Recombinant, Mouse

Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2/IL-36R and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response, similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. {ECO:0000269, PubMed:17908936, ECO:0000269, PubMed:18284608, ECO:0000269, PubMed:21860022, ECO:0000269, PubMed:21965679}. Biological Activity: Measured by its ability to inhibit IL-36gamma induced IL-6 production by human PBMCs. Sequence: VLSGALCFRM KDSALKVLYL HNNQLLAGGL HAEKVIKGEE ISVVPNRALD ASLSPVILGV QGGSQCLSCG TEKGPILKLE PVNIMELYLG AKESKSFTFY RRDMGLTSSF ESAAYPGWFL CTSPEADQPV RLTQIPEDPA WDAPITDFYF QQCD, Molecular Weight: 16.9kD, PubMed ID: 11093146, 10744718, 11466363, 16141072, 17908936, 18284608, 21860022, 21965679, 12974628, Gene Name: IL36RN, Fil1d, Il1f5, Il1h3, Il1hy1, Swiss Prot: Q9QYY1, Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.