Interleukin-27, HEK, human recombinant (rHuIL-27-HEK)

Interleukin-27, HEK, human recombinant (rHuIL-27-HEK)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
97587.1 1 µg - -

3 - 10 business days*

97587.5 5 µg - -

3 - 10 business days*

97587.100 100 µg - -

3 - 10 business days*

Human recombinant IL-27produced in HEK cells is a glycosylated heterodimer, having a molecular... more
Product information "Interleukin-27, HEK, human recombinant (rHuIL-27-HEK)"

Human recombinant IL-27produced in HEK cells is a glycosylated heterodimer, having a molecular weight range of 25-30kDa due to glycosylation. Interleukin-27 protein is related to IL-12A and is one of the subunits of a heterodimeric cytokine complex. IL-27 interacts with EBV induced gene 3 also called EBI3, and forms a complex that drives rapid expansion of CD4 (+) T cells. IL-27 complex is synergizes with IL-12 in order to trigger the cytokine production of IFN-Gamma of CD4 (+) T cells. The biological effect of IL-27 is mediated by class-I cytokine receptor (WSX1/TCRR). The pro-inflammatory activity of IL-27 is mediated through the growing expression of key molecules involved in the MHC class-I and MHC class-II pathways. Both MHC class-I and MHC-class-II expression are increased in endothelial cells after Interleukin-27 stimulation which suggests that it may play an important role in conferring the immune function on vascular endothelium IL-27p28 subunit can be induced by IFN-beta and during LPS-induced maturation of dendritic cells in type-I IFN-dependent manner through IFN regulatory factor-1 activation. Interleukin-27 regulates Interleukin-12 responsiveness of CD4+ T-cells through Stat1-dependent and -independent mechanisms. IL-17 and IL-23 play an important IL-17 role in inflammation. Interleukin-27 possesses potent anti-angiogenic activity that plays an important role in its antitumor and antimetastatic activities. EBV induced gene 3 plays a role, independently from IL-27, in regulating anti-viral or anti-tumoral immune responses. Interleukin-27 is a potent inhibitor of HIV-1 replication in macrophages, CD4+ T cells, peripheral blood mononuclear cells. Interleukin-27 triggers STAT activation and gene transcription.

Keywords: p28, IL27, IL27A, IL27-A, IL-27-A, IL-27 subunit alpha, EBI3, IL27B, IL-27B, IL-27 subunit beta, Interleukin-27 subunit alpha, EBV-induced gene 3 protein, Interleukin-27 subunit beta, Epstein-Barr virus-induced gene 3 protein
Supplier: Biomol GmbH
Supplier-Nr: 97587


Application: Cell Culture
Conjugate: No
Expressed in: Human cells
Origin: Human
Purity: >90%
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Our products are for laboratory research use only: Not for administration to humans!
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