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Human recombinant IL-23 produced in HEK 293 cells is a heterodimer (IL23A co-transfected with IL12B), containing one polypeptide chain of IL23 protein (19.77kDa) fused with a C-terminal His tag and one polypeptide chain of IL12b-Flag (35.69kDa). IL23 is composed of a subunit of the heterodimeric cytokine IL23 and the p40 subunit of interleukin 12 (IL12B). Interleukin-23 (IL-23) belongs to the IL-12 family and is produced by antigen presenting cells. IL-23 using IL12RB1 and IL-23R (specific for IL-23) can activate STAT and NF-kappaB pathways and stimulate the production of interferon-gamma.). IL-23 is known to take a vital part in the inflammation process and is associated with auto immune diseases. However, unlike IL12, which acts primarily on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells.
Keywords: | Interleukin 23 alpha subunit p19, Interleukin-12 subunit beta p40, SGRF, IL23P19, IL-23-A, interleukin-six, G-CSF related factor, JKA3 induced upon T-cell activation, interleukin 12B (natural killer cell stimulatory factor 2 cytotoxic lymphocyte maturatio |
Supplier: | Biomol GmbH |
Supplier-Nr: | 97503.2 |
Properties
Application: | Bioassay |
Conjugate: | No |
Expressed in: | Human cells |
Origin: | Human |
Purity: | >90% |
Format: | Solution |
Database Information
KEGG ID : | K05426 | Find alternatives |
UniProt ID : | Q9NPF7 | Find alternatives |
Gene ID | GeneID 51561 | Find alternatives |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Our products are for laboratory research use only: Not for administration to humans!