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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating... more
Product information "Interleukin-13 Variant (IL-13), human recombinant (rHuIL-13)"
Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. (www.uniprot.org) Human recombinant Interleukin-13 Variant produced in E.coli is a single, non-glycosylated polypeptide chain containing 114 amino acids, with a substitution of Q for R at position 112 compared with the wild type IL-13, having a molecular mass of 12.5 kDa. IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells. IL-13 is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL-3, IL-5, IL-4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL-4.
Keywords: | Interleukin-13, NC30, ALRH, BHR1, P600, IL-13, MGC116786, MGC116788, MGC116789 |
Supplier: | Biomol GmbH |
Supplier-Nr: | 97296 |
Properties
Application: | Cell culture |
Conjugate: | No |
Host: | E.coli |
Species reactivity: | human |
MW: | 12500 D |
Purity: | >95% |
Format: | Purified |
Database Information
KEGG ID : | K05435 | Matching products |
UniProt ID : | P35225 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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