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Interferon Gamma-Inducible protein 30, His tag, human recombinant (rHuIFI30-His)
Product information "Interferon Gamma-Inducible protein 30, His tag, human recombinant (rHuIFI30-His)"
IFI30 human recombinant produced in E. coli is a single polypeptide chain containing 199 amino acids (58-232) and having a molecular mass of 22.5 kDa. IFI30 is fused to a 24 amino acid His-tag at N-terminus. Gamma-interferon-inducible lysosomal thiol reductase (IFI30), is a part of the GILT family. IFI30 is a lysosomal thiol reductase which at low pH is capable of decreasing protein's disulfide bonds. IFI30 is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. Also, IFI30 plays an important role in MHC class II-restricted antigen processing. IFI30 facilitates the generation of MHC class II-restricted epitopes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds and also facilitates MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or cross-presentation.
Keywords:
Interferon Gamma-Inducible Protein 30, Gamma-Interferon-Inducible Lysosomal Thiol Reductase, Interferon Gamma-Inducible Protein 30 Preproprotein, Gamma-Interferon-Inducible Protein IP-30, Legumaturain, GILT, IP30, IFI-30, MGC32056, EC 1.8.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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