IL-5 protein (His tag), recombinant rat

Activity: Testing in progress Protein Construction: A DNA sequence encoding the Rat IL-5 protein (Q08125) (Met1-Val132) was expressed with a C-His. Sequence: Met1-Val132. Fusion tag: C-His Endotoxin: Please contact us for more information. Apparent Molecular Mass: 25 kDa. Protein function: Interleukin 5 (IL-5) is a member of the interleukin family. Interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes) and has been found in a wide variety of body c Protein function: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:10446387). Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively. [The UniProt Consortium]