IL-34, Human

Sequence: MNEPLEMWPL TQNEECTVTG FLRDKLQYRS RLQYMKHYFP INYKISVPYE GVFRIANVTR LQRAQVSERE LRYLWVLVSL SATESVQDVL HPSWKYLQEV ETLLLNVQQG LTDVEVSPKV ESVLSLLNAP GPNLKLVRPK ALLDNCFRVM ELLYCSCCKQ SSVLNWQDCE VPSPQSCSPE LQYAATQLYP PPPWSPSSPP HSTGSVRPVR with polyhistidine tag at the C-terminus Endotoxin level: <0.1 EU per 1 µg of the protein by the LAL method. Protein function: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. [The UniProt Consortium]