IL-1 beta, Human

Sequence: MASAPVRSLN CTLRDSQQKS LVMSGPYELK ALHLQGQDME QQVVFSMSFV QGEESNDKIP VALGLKEKNL YLSCVLKDDK PKNYPKKKME KRFVFNKIEI NNKLEFESAQ FPNWYISTSQ AENMPVFLGG TKGGQDITDF with polyhistidine tag at the C-terminus Endotoxin level: <0.1 EU per 1 µg of the protein by the LAL method. Protein function: Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells (PubMed:10653850). Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6 (PubMed:12794819). [The UniProt Consortium]