Heparin Binding EGF like Growth Factor/proHB-EGF Protein(C-6His) (recombinant human)

Heparin Binding EGF like Growth Factor/proHB-EGF Protein(C-6His) (recombinant human)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-PKSH032533.10 10 µg - -

7 - 16 business days*

68.00€
E-PKSH032533.50 50 µg - -

7 - 16 business days*

155.00€
 
Protein Construction: Recombinant Human Heparin Binding EGF like Growth Factor is produced by our... more
Product information "Heparin Binding EGF like Growth Factor/proHB-EGF Protein(C-6His) (recombinant human)"
Protein Construction: Recombinant Human Heparin Binding EGF like Growth Factor is produced by our Mammalian expression system and the target gene encoding Leu20-Leu148 is expressed with a 6His tag at the C-terminus. Sequence: Leu20-Leu148. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 18 kDa. Protein function: Heparin-binding EGF-like growth factor (HB-EGF) is a 12-16 kDa member of the epidermal growth factor (EGF) family. It possesses an EGF-like domain, and a heparin-binding motif. Mature HB-EGF is a soluble peptide that arises from proteolytic processing of the transmembrane form. Human HB-EGF shows 76% and 73% aa sequence identity with rat and mouse HB-EGF, respectively. It is required for normal cardiac valve formation and normal heart function, promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation, it is mitogenic for fibroblasts, but not endothelial cells. HB-EGF classified as a group 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors. Activity associated with ErbB4 binding appears to be limited to non-mitogenic actions, while EGFR binding induces both mitogenic and non-mitogenic activity. Protein function: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor. [The UniProt Consortium]
Keywords: DTR, HBEGF, Recombinant Human Heparin Binding EGF like Growth Factor/proHB-EGF Protein(C-6His)
Supplier: Elabscience
Supplier-Nr: E-PKSH032533

Properties

Conjugate: No
Expressed in: Human cells
Origin: Human
MW: 15.1 kD
Format: Lyophilized

Handling & Safety

Storage: -80°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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