Fractalkine, Recombinant, Human (FKN, A-152E5.2, ABCD-3, Chemokine (C-X3-C Motif) Ligand 1, C-X3-C M

AHP453B is specific for human fractalkine, otherwise known as CX3CL1, a 397aa CX3C chemokine which signals through the CX3CR1 receptor and is expressed by various tissues including the brain, testis, lung, heart, kidney, colon and skeletal muscle. Adhesion of fractalkine to the CX3CR1 receptor triggers the chemotaxis and adhesion of leukocytes, including T cells, monocytes and NK cells and studies have suggested that fractalkine is involved in the regulation of brain microglia during neuroinflammatory processes (1) and may play a role in dendritic cell-mediated host defense against invading pathogens such as Legionella pneumophila (2). , Source:, Recombinant corresponding to human Fractalkine. Applications: Suitable for use in Functional Assays. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: , Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.