Activin B, Human

Sequence: MGLECDGRTN LCCRQQFFID FRLIGWNDWI IAPTGYYGNY CEGSCPAYLA GVPGSASSFH TAVVNQYRMR GLNPGTVNSC CIPTKLSTMS LYFDDEYNIV KRDVPNMIVE with polyhistidine tag at the C-terminus Endotoxin level: <0.1 EU per 1 µg of the protein by the LAL method. Protein function: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. [The UniProt Consortium]