Verruculogen

White to off-white solid. Soluble in DMSO, 100% ethanol, methanol or dichloromethane. Fumitremorgin-type alkaloid, Tremorgenic neurotoxic mycotoxin, Selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK, maxi-K) channels, Decreases GABA levels in CNS, Increases spontaneous glutamate and aspartate release, At toxic doses, increases the number and decreases the affinity of DHP receptors in rat cortex, Cell cycle inhibitor at the M phase, Inhibits calmodulin and PKC activity, Has apoptotic effects on human T lymphocytes, Stimulates the growth of seedling roots of buckwheat.