25 products were found matching "K04936"!

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Penitrem A
Penitrem A

Item number: Cay11347-1

Penitrem A is a tremorgenic fungal toxin that acts as an inhibitor of large-conductance calcium-activated potassium channels KCa1.1/BK, inhibiting the binding of charybdotoxin with an IC50 value of 1.7 µM. It is currently used to evaluate the role of KCa1.1-mediated potassium flux in various cell processes and...
Keywords: NSC 354845, Tremortin A,...
Application: BKCa inhibitor
CAS 12627-35-9
MW: 634.2 D
From 56.00€ *
Review
Paxilline
Paxilline

Item number: Cay11345-5

Paxilline is an indole diterpene from fungi which potently and reversibly inhibits large conductance Ca2+-activated K+ (BKCa) channels, as shown in patch clamp (Ki = 1.9 nM) and whole smooth muscle cell studies (Ki = 35.7 nM). It also enhances the binding of charybdotoxin (Cay-24115), a peptidyl neurotoxin, to BKCa...
Keywords: 5,6,6a,7,12,12bS,12cR,13,14,14aS-decahydro-4bS-hydroxy-2R-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-1-benzopyrano[5',6...
Application: BKCa channel inhibitor
CAS 57186-25-1
MW: 435.6 D
From 61.00€ *
Review
Verruculogen
Verruculogen

Item number: Cay11351-1

Verruculogen is a tremorgenic mycotoxin isolated from species of Penicillium, Aspergillus, and other fungi. It selectively inhibits the activation of large-conductance calcium-activated potassium channels (KCa1.1/BK) potassium channels by charybdotoxin with a K1/2 value of 170 nM. Verruculogen also promotes the...
Keywords: NA 209A, TR 1,...
Application: Inhibitor of BK channel activation by charybdotoxin
CAS 12771-72-1
MW: 511.6 D
From 134.00€ *
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NS 11021
NS 11021

Item number: Cay15347-1

NS 11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa/KCa1.1). It is selective for BKCa and is thought to bind directly the alpha subunit. NS 11021 has been shown to relax intracavernous arterial rings and corpus cavernosum strips in vitro and to enhance erectile responses in intact...
Keywords: N'-[3,5-bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-thiourea
Application: KCNMA1 activator
CAS 956014-19-0
MW: 511.2 D
From 43.00€ *
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NS 1619
NS 1619

Item number: Cay18876-10

NS 1619 is a calcium-dependent activator of large-conductance calcium-activated potassium (KCa1.1/BK) channels in vascular smooth muscle. It is typically used at a concentration of 30 µM to hyperpolarize the membrane potential of single myocytes during studies of smooth muscle relaxation and vasodilation. Studies...
Keywords: 1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one
Application: BKCa channel agonist
CAS 153587-01-0
MW: 362.2 D
From 50.00€ *
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BMS 204352
BMS 204352

Item number: Cay29378-1

BMS 204352 is an activator of large-conductance calcium-activated potassium (KCa1.1/BK) channels that increases KCa1.1 currents in X. laevis oocytes expressing human KCa1.1 in a calcium- and concentration-dependent manner. It decreases electrically induced population excitatory postsynaptic potentials (pEPSPs) in...
Keywords: (+)-BMS 204352, (3S)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-indol-2-one
Application: BKCa channel activator
CAS 187523-35-9
MW: 359.7 D
From 50.00€ *
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Anti-KCNMA1
Anti-KCNMA1

Item number: A303-409A

Protein function: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the...
Keywords: Anti-hSlo, Anti-Slo1, Anti-KCNMA, Anti-MaxiK, Anti-KCNMA1, Anti-KCa1.1, Anti-Slo-alpha, Anti-BK channel, Anti-BKCA alpha,...
Application: WB, IP
Host: Rabbit
Species reactivity: human
From 164.00€ *
Review
Iberiotoxin (trifluoroacetate salt)
Iberiotoxin (trifluoroacetate salt)

Item number: Cay14608-100

Iberiotoxin, a peptide purified from venom of the scorpion B. tamulus, is a selective blocker of large-conductance calcium-activated potassium channels (KCa1.1/BKCa). In single channel recordings, iberiotoxin can reversibly block outward currents mediated by KCa1.1 in excised membrane patches from bovine aortic...
Keywords: 4-L-aspartic acid-6-L-aspartic acid-8-L-serine-9-L-valine-18-L-lysine-19-L-aspartic...
Application: BKCa blocker
CAS 182897-30-9
MW: 4230.9 D
448.00€ *
Review
Anti-mSlo maxi- K channel, clone S6-60
Anti-mSlo maxi- K channel, clone S6-60

Item number: 200-301-G15

Anti-Mslo maxi- K channel Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Mslo from Mouse, Human, Rat, and Zebrafish based on 100% homology with the immunizing sequence. Cross-reactivity with Mslo from other sources has not been determined. Ion Channels...
Keywords: Anti-mSlo, Anti-Slo1, Anti-Kcnma, Anti-mSlo1, Anti-MaxiK, Anti-Kcnma1, Anti-KCa1.1, Anti-Slo-alpha, Anti-BKCA alpha,...
Application: IHC, IFM, IP, WB
Host: Mouse
Species reactivity: mouse, human, rat, zebrafish
698.00€ *
Review
Anti-BK channel (KCNMA1)
Anti-BK channel (KCNMA1)

Item number: NSJ-R31640

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Calcium-activated potassium channel subunit alpha-1 also known as KCa1.1, BK channel and Maxi K, is a voltage gated potassium channel encoded by the KCNMA1 gene and characterized by its large conductance of potassium ions (K+) through cell membranes. This gene...
Keywords: Anti-Slo1, Anti-hSlo, Anti-MaxiK, Anti-KCNMA, Anti-KCa1.1, Anti-KCNMA1, Anti-Slo-alpha, Anti-BKCA alpha, Anti-BK channel,...
Application: WB, IHC (paraffin)
Host: Rabbit
Species reactivity: human, mouse, rat
755.00€ *
Review
-10 %
Verruculogen
Verruculogen

Item number: BVT-0443-M001

White to off-white solid. Soluble in DMSO, 100% ethanol, methanol or dichloromethane. Fumitremorgin-type alkaloid, Tremorgenic neurotoxic mycotoxin, Selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK, maxi-K) channels, Decreases GABA levels in CNS, Increases spontaneous glutamate and aspartate...
Keywords: NA 209A, TR 1
Application: Selective KCNMA1 / KCa1.1 / BK channel blocker
CAS 12771-72-1
MW: 511,6 D
120.00€ * 108.00€ *
Review
-10 %
Paxilline
Paxilline

Item number: AG-CN2-0167-M001

Off-white solid. Soluble in DMSO, methanol or ethanol. Tremorgenic, Potent, selective and reversible inhibitor of high-conductance calcium-activated potassium (BKCa) channels, Reversible inhibitor of inositol 1,4,5-trisphosphate receptor (InsP(3)), Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor, Liver X...
Keywords: BRN 5317894, NSC 658707
Application: High-conductance calcium-activated potassium (BKCa) channel inhibitor, SERCA inhibitor
CAS 57186-25-1
MW: 435,6 D
50.00€ * From 45.00€ *
Review
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